The Effects of Regular Tanning Bed Use and Increased Vitamin D Status on Serum Markers of Bone Turnover in Healthy Adult Women Export

@article{citeulike:6095712, abstract = {BACKGROUND: Vitamin D is a key nutrient in bone health and the vitamin D status of individuals with regular exposure to solar or artificial ultraviolet B (UVB) radiation is generally superior to those with limited exposure. OBJECTIVE: By means of a cross-sectional, observational design, explore the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations and biochemical markers of bone turnover across a spectrum of vitamin D status by comparing women who regularly use tanning beds with women of minimal UVB exposure. METHODS: A total of 69 healthy women, ages 25–82y, were recruited. Serum concentrations of 25(OH)D, intact parathyroid hormone (iPTH), leptin, bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and C-terminal telopeptides of Type I collagen (CTx) were measured. RESULTS: There were no significant differences in age, height, weight, BMI and dietary intakes between groups. Serum 25(OH)D concentrations were significantly higher in tanners (n = 20) compared with non-tanners (n = 49) (p < 0.0001). Serum iPTH concentrations were lower in tanners than in non-tanners (p < 0.0001) and were negatively correlated with serum 25(OH)D concentrations (r = –4571, p < 0.0001). Of the bone turnover markers, only serum OC concentrations were lower in tanners compared with non-tanners (p = 0.0002). After adjusting for age and menopausal status, osteocalcin was negatively correlated (r = –0.0178; p = 0.04) with 25(OH)D and positively correlated with iPTH (r = 0.035; p = 0.05). CONCLUSIONS: Our results show healthy women with regular UVB exposure via tanning beds have significantly greater vitamin D status and lower serum osteocalcin concentrations than those without and that there is a significant inverse relationship between serum serum 25(OH)D and osteocalcin concentrations which appears to be PTH-dependent. --- Categories: Womens' health --- Keywords: vitamin D, tanning, bone markers, vitamin D status, bone health, women–}, author = {Peterson, Catherine A. and Heffernan, Mary E. and Sisk, Kay A. and Ring, Susan M.}, citeulike-article-id = {6095712}, citeulike-linkout-0 = {http://scholar.google.com/scholar?q=The+Effects+of+Regular+Tanning+Bed+Use+and+Increased+Vitamin+D+Status+on+Serum+Markers+of+Bone+Turnover+in+Healthy+Adult+Women}, citeulike-linkout-1 = {http://scholar.google.com/scholar?cluster=10189319046667764902}, citeulike-linkout-2 = {http://www.la-press.com/the-effects-of-regular-tanning-bed-use-and-increased-vitamin-d-status--a1289}, journal = {Clinical Medicine:Women's Health}, keywords = {biomarkers\_bone, bone\_health, skin, tanning\_beds, vit\_d}, pages = {1--7}, posted-at = {2009-11-10 19:41:38}, priority = {2}, title = {The Effects of Regular Tanning Bed Use and Increased Vitamin D Status on Serum Markers of Bone Turnover in Healthy Adult Women}, url = {http://scholar.google.com/scholar?q=The+Effects+of+Regular+Tanning+Bed+Use+and+Increased+Vitamin+D+Status+on+Serum+Markers+of+Bone+Turnover+in+Healthy+Adult+Women}, volume = {2}, year = {2009} }

TY - JOUR ID - citeulike:6095712 L3 - citeulike-article-id:6095712 N2 - BACKGROUND: Vitamin D is a key nutrient in bone health and the vitamin D status of individuals with regular exposure to solar or artificial ultraviolet B (UVB) radiation is generally superior to those with limited exposure. OBJECTIVE: By means of a cross-sectional, observational design, explore the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations and biochemical markers of bone turnover across a spectrum of vitamin D status by comparing women who regularly use tanning beds with women of minimal UVB exposure. METHODS: A total of 69 healthy women, ages 25–82y, were recruited. Serum concentrations of 25(OH)D, intact parathyroid hormone (iPTH), leptin, bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and C-terminal telopeptides of Type I collagen (CTx) were measured. RESULTS: There were no significant differences in age, height, weight, BMI and dietary intakes between groups. Serum 25(OH)D concentrations were significantly higher in tanners (n = 20) compared with non-tanners (n = 49) (p < 0.0001). Serum iPTH concentrations were lower in tanners than in non-tanners (p < 0.0001) and were negatively correlated with serum 25(OH)D concentrations (r = –4571, p < 0.0001). Of the bone turnover markers, only serum OC concentrations were lower in tanners compared with non-tanners (p = 0.0002). After adjusting for age and menopausal status, osteocalcin was negatively correlated (r = –0.0178; p = 0.04) with 25(OH)D and positively correlated with iPTH (r = 0.035; p = 0.05). CONCLUSIONS: Our results show healthy women with regular UVB exposure via tanning beds have significantly greater vitamin D status and lower serum osteocalcin concentrations than those without and that there is a significant inverse relationship between serum serum 25(OH)D and osteocalcin concentrations which appears to be PTH-dependent. --- Categories: Womens' health --- Keywords: vitamin D, tanning, bone markers, vitamin D status, bone health, women– JF - Clinical Medicine:Women's Health EP - 7 TI - The Effects of Regular Tanning Bed Use and Increased Vitamin D Status on Serum Markers of Bone Turnover in Healthy Adult Women VL - 2 SP - 1 KW - biomarkers_bone KW - bone_health KW - skin KW - tanning_beds KW - vit_d AU - Peterson, Catherine AU - Heffernan, Mary AU - Sisk, Kay AU - Ring, Susan PY - 2009/// UR - http://scholar.google.com/scholar?q=The+Effects+of+Regular+Tanning+Bed+Use+and+Increased+Vitamin+D+Status+on+Serum+Markers+of+Bone+Turnover+in+Healthy+Adult+Women ER -