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Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Export

Nature reviews. Cancer, Vol. 3, No. 8. (August 2003), pp. 601-614.

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calcium cancerprevention colon_cancer folate vit_d_signaling

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Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.


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