ajaymalik's cyp [3 articles]

Abstract

Steroid hormones including (1,25)-dihydroxy vitamin D3, estrogens and glucocorticoids control bone development and homeostasis. We show here that the osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1, Cyp39a1, Cyp51, Lss and Dhcr7 in murine osteoprogenitor cells. Cyp11a1 (P450scc) encodes a ~55 kDa mitochondrial enzyme that catalyzes side-chain cleavage of cholesterol and is rate-limiting for steroid hormone biosynthesis. Runx2 is co-expressed with Cyp11a1 in osteoblasts, as well as non-osseous cell types (e.g., testis and breast cancer cells), suggesting ...

Abstract

Epidemiologic studies suggest that nutritional phytoestrogens contained in soy are causally related to protection against hormone-dependent cancers. The incidence of colorectal cancer is at least 30% lower in women than in men in the United States. This suggests that estrogen and, conceivably, nutritional phytoestrogens are protective compounds against colorectal cancer for both sexes. Prevention of colorectal, mammary, and prostate cancer may also depend on optimal synthesis of the antimitotic prodifferentiating vitamin D hormonal metabolite 1,25-(OH)2-cholecalciferol (1,25-D3). Cytochrome-P450-hydroxylases responsible for synthesis (CYP27B1; ...