Covariance of isometric and dynamic arm contractions: Multivariate genetic analysis Export

@article{citeulike:1770125, abstract = {The purpose of the present study was to examine genetic and environmental contributions to individual differences in maximal isometric, concentric and eccentric muscle strength and muscle cross-sectional area (MCSA) of the elbow flexors. A generality versus specificity hypothesis was explored to test whether the 4 strength variables share a genetic component or common factors in the environment or whether the genetic/environmental factors are specific for each strength variable. The 4 variables under study were measured in 25 monozygotic and 16 dizygotic male Caucasian twin pairs (22.4 ± 3.7 years). The multivariate genetic analyses showed that all 4 variables shared a genetic and environmental component, which accounted for 43\% and 6\% in MCSA (h2 = 81 \%), 47\% and 20\% in eccentric (h2 = 65\%), 58\% and 4\% in isometric (h2 = 70\%) and 32\% and 1\% in concentric strength (h2 = 32\%) respectively. The remaining variation was accounted for by contraction type specific and muscle cross-sectional area specific genetic and environmental effects, which accounted for 38\% and 14\% in MCSA, 18\% and 15\% in eccentric, 12\% and 26\% in isometric and 0\% and 67\% in concentric strength respectively. This exploratory multivariate study suggests shared pleiotropic gene action for MCSA, eccentric, isometric and concentric strength, with a moderate to high genetic contribution to the variability of these characteristics.}, address = {Department of Biomedical Kinesiology, Research Center for Exercise and Health, Katholieke Universiteit Leuven, Tervuursevest 101, B-3001 Leuven, Belgium}, author = {De Mars, G. and Thomis, M. A. I. and Windelinckx, A. and Van Leemputte, M. and Maes, H. H. and Blimkie, C. J. and Claessens, A. L. and Vlietinck, R. and Beunen, G.}, citeulike-article-id = {1770125}, citeulike-linkout-0 = {http://dx.doi.org/10.1375/twin.10.1.180}, citeulike-linkout-1 = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-33947195723}, doi = {10.1375/twin.10.1.180}, journal = {Twin Res. Hum. Genet.}, keywords = {covariance, exercise, genes, multivariate}, number = {1}, pages = {180--190}, posted-at = {2007-10-15 13:53:17}, priority = {2}, title = {Covariance of isometric and dynamic arm contractions: Multivariate genetic analysis}, url = {http://dx.doi.org/10.1375/twin.10.1.180}, volume = {10}, year = {2007} }

TY - JOUR ID - citeulike:1770125 L3 - citeulike-article-id:1770125 N2 - The purpose of the present study was to examine genetic and environmental contributions to individual differences in maximal isometric, concentric and eccentric muscle strength and muscle cross-sectional area (MCSA) of the elbow flexors. A generality versus specificity hypothesis was explored to test whether the 4 strength variables share a genetic component or common factors in the environment or whether the genetic/environmental factors are specific for each strength variable. The 4 variables under study were measured in 25 monozygotic and 16 dizygotic male Caucasian twin pairs (22.4 ± 3.7 years). The multivariate genetic analyses showed that all 4 variables shared a genetic and environmental component, which accounted for 43% and 6% in MCSA (h2 = 81 %), 47% and 20% in eccentric (h2 = 65%), 58% and 4% in isometric (h2 = 70%) and 32% and 1% in concentric strength (h2 = 32%) respectively. The remaining variation was accounted for by contraction type specific and muscle cross-sectional area specific genetic and environmental effects, which accounted for 38% and 14% in MCSA, 18% and 15% in eccentric, 12% and 26% in isometric and 0% and 67% in concentric strength respectively. This exploratory multivariate study suggests shared pleiotropic gene action for MCSA, eccentric, isometric and concentric strength, with a moderate to high genetic contribution to the variability of these characteristics. IS - 1 JF - Twin Res. Hum. Genet. AD - Department of Biomedical Kinesiology, Research Center for Exercise and Health, Katholieke Universiteit Leuven, Tervuursevest 101, B-3001 Leuven, Belgium EP - 190 TI - Covariance of isometric and dynamic arm contractions: Multivariate genetic analysis VL - 10 SP - 180 KW - covariance KW - exercise KW - genes KW - multivariate AU - De Mars, G AU - Thomis, MAI AU - Windelinckx, A AU - Van Leemputte, M AU - Maes, HH AU - Blimkie, CJ AU - Claessens, AL AU - Vlietinck, R AU - Beunen, G PY - 2007/// UR - http://dx.doi.org/10.1375/twin.10.1.180 ER -