Integrating pharmacokinetics knowledge into a drug ontology: as an extension to support pharmacogenomics. Export

@article{citeulike:2864396, abstract = {The newly developed U.S. Common Medication Information Infrastructure was used as a basis to capture and formally express the properties of drugs relevant to research and the clinical application of pharmacogenomics. Two associated taxonomies within the model, Mechanism of Action and Physiologic Effect, were enriched to accommodate pharmacogenomic use-cases; the 4,000 active ingredients in the VA NDF-RT drug file were related to the enhanced taxonomies. Pharmacokinetics were independently modeled for pharmacogenomics and tested against thirty-one high-profile drugs to demonstrate our approach.}, address = {Division of Medical Informatics Research, Mayo Clinic, Rochester, MN, USA.}, author = {Chute, C. G. and Carter, J. S. and Tuttle, M. S. and Haber, M. and Brown, S. H.}, citeulike-article-id = {2864396}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/14728156}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=14728156}, issn = {1559-4076}, journal = {AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium}, keywords = {medical, ontology}, pages = {170--174}, posted-at = {2008-06-05 12:11:11}, priority = {2}, title = {Integrating pharmacokinetics knowledge into a drug ontology: as an extension to support pharmacogenomics.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14728156}, year = {2003} }

TY - JOUR ID - citeulike:2864396 L3 - citeulike-article-id:2864396 N2 - The newly developed U.S. Common Medication Information Infrastructure was used as a basis to capture and formally express the properties of drugs relevant to research and the clinical application of pharmacogenomics. Two associated taxonomies within the model, Mechanism of Action and Physiologic Effect, were enriched to accommodate pharmacogenomic use-cases; the 4,000 active ingredients in the VA NDF-RT drug file were related to the enhanced taxonomies. Pharmacokinetics were independently modeled for pharmacogenomics and tested against thirty-one high-profile drugs to demonstrate our approach. JF - AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium SN - 1559-4076 AD - Division of Medical Informatics Research, Mayo Clinic, Rochester, MN, USA. EP - 174 TI - Integrating pharmacokinetics knowledge into a drug ontology: as an extension to support pharmacogenomics. SP - 170 KW - medical KW - ontology AU - Chute, CG AU - Carter, JS AU - Tuttle, MS AU - Haber, M AU - Brown, SH PY - 2003/// UR - http://view.ncbi.nlm.nih.gov/pubmed/14728156 ER -