Whole-Genome Patterns of Common DNA Variation in Three Human Populations Export

@article{citeulike:99033, abstract = {Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry. Our results indicate that these SNPs capture most common genetic variation as a result of linkage disequilibrium, the correlation among common SNP alleles. We observe a strong correlation between extended regions of linkage disequilibrium and functional genomic elements. Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations.}, author = {Hinds, David A. and Stuve, Laura L. and Nilsen, Geoffrey B. and Halperin, Eran and Eskin, Eleazar and Ballinger, Dennis G. and Frazer, Kelly A. and Cox, David R.}, citeulike-article-id = {99033}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1105436}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/307/5712/1072}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15718463}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15718463}, citeulike-linkout-4 = {http://www.sciencemag.org/cgi/content/full/307/5712/1072}, day = {18}, doi = {10.1126/science.1105436}, journal = {Science}, keywords = {genetics, human, population}, month = {February}, number = {5712}, pages = {1072--1079}, posted-at = {2005-03-31 22:24:04}, priority = {0}, title = {Whole-Genome Patterns of Common DNA Variation in Three Human Populations}, url = {http://dx.doi.org/10.1126/science.1105436}, volume = {307}, year = {2005} }

TY - JOUR ID - citeulike:99033 L3 - citeulike-article-id:99033 N2 - Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotide polymorphisms (SNPs) in 71 Americans of European, African, and Asian ancestry. Our results indicate that these SNPs capture most common genetic variation as a result of linkage disequilibrium, the correlation among common SNP alleles. We observe a strong correlation between extended regions of linkage disequilibrium and functional genomic elements. Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations. IS - 5712 JF - Science EP - 1079 TI - Whole-Genome Patterns of Common DNA Variation in Three Human Populations VL - 307 SP - 1072 KW - genetics KW - human KW - population AU - Hinds, David AU - Stuve, Laura AU - Nilsen, Geoffrey AU - Halperin, Eran AU - Eskin, Eleazar AU - Ballinger, Dennis AU - Frazer, Kelly AU - Cox, David PY - 2005/02/18/ UR - http://dx.doi.org/10.1126/science.1105436 ER -