Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.
by: Robert M. Waterhouse, Evgenia V. Kriventseva, Stephan Meister, Zhiyong Xi, Kanwal S. Alvarez, Lyric C. Bartholomay, Carolina Barillas-Mury, Guowu Bian, Stephanie Blandin, Bruce M. Christensen, Yuemei Dong, Haobo Jiang, Michael R. Kanost, Anastasios C. Koutsos, Elena A. Levashina, Jianyong Li, Petros Ligoxygakis, Robert M. Maccallum, George F. Mayhew, Antonio Mendes, Kristin Michel, Mike A. Osta, Susan Paskewitz, Sang Woon W. Shin, Dina Vlachou, Lihui Wang, Weiqi Wei, Liangbiao Zheng, Zhen Zou, David W. Severson, Alexander S. Raikhel, Fotis C. Kafatos, George Dimopoulos, Evgeny M. Zdobnov, George K. Christophides
Science (New York, N.Y.), Vol. 316, No. 5832. (22 June 2007), pp. 1738-1743, doi:10.1126/science.1139862 Key: citeulike:3187174
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Abstract
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
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