Neocortical neurogenesis in humans is restricted to development. Export

@article{citeulike:1206137, abstract = {Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.}, address = {Department of Cell and Molecular Biology, Medical Nobel Institute, and Department of Forensic Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden.}, author = {Bhardwaj, R. D. and Curtis, M. A. and Spalding, K. L. and Buchholz, B. A. and Fink, D. and Bj\"{o}rk-Eriksson, T. and Nordborg, C. and Gage, F. H. and Druid, H. and Eriksson, P. S. and Fris\'{e}n, J.}, citeulike-article-id = {1206137}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0605177103}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16901981}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16901981}, day = {15}, doi = {10.1073/pnas.0605177103}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {adult, human, ng}, month = {August}, number = {33}, pages = {12564--12568}, posted-at = {2007-04-04 15:56:02}, priority = {2}, title = {Neocortical neurogenesis in humans is restricted to development.}, url = {http://dx.doi.org/10.1073/pnas.0605177103}, volume = {103}, year = {2006} }

TY - JOUR ID - citeulike:1206137 L3 - citeulike-article-id:1206137 N2 - Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally. IS - 33 JF - Proc Natl Acad Sci U S A SN - 0027-8424 AD - Department of Cell and Molecular Biology, Medical Nobel Institute, and Department of Forensic Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden. EP - 12568 TI - Neocortical neurogenesis in humans is restricted to development. VL - 103 SP - 12564 KW - adult KW - human KW - ng AU - Bhardwaj, RD AU - Curtis, MA AU - Spalding, KL AU - Buchholz, BA AU - Fink, D AU - Björk-Eriksson, T AU - Nordborg, C AU - Gage, FH AU - Druid, H AU - Eriksson, PS AU - Frisén, J PY - 2006/08/15/ UR - http://dx.doi.org/10.1073/pnas.0605177103 ER -