Importance of newly generated neurons in the adult olfactory bulb for odor discrimination Export

@article{citeulike:489951, abstract = {In adult rodents, neurons are continually generated in the subventricular zone of the forebrain, from where they migrate tangentially toward the olfactory bulb, the only known target for these neuronal precursors. Within the main olfactory bulb, they ascend radially into the granule and periglomerular cell layers, where they differentiate mainly into local interneurons. The functional consequences of this permanent generation and integration of new neurons into existing circuits are unknown. To address this question, we used neural cell adhesion molecule-deficient mice that have documented deficits in the migration of olfactory-bulb neuron precursors, leading to about 40\% size reduction of this structure. Our anatomical study reveals that this reduction is restricted to the granule cell layer, a structure that contains exclusively \^{I}³-aminobutyric acid (GABA)ergic interneurons. Furthermore, mutant mice were subjected to experiments designed to examine the behavioral consequences of such anatomical alteration. We found that the specific reduction in the newly generated interneuron population resulted in an impairment of discrimination between odors. In contrast, both the detection thresholds for odors and short-term olfactory memory were unaltered, demonstrating that a critical number of bulbar granule cells is crucial only for odor discrimination but not for general olfactory functions.}, address = {Centre National de la Recherche Scientifique, Institut Alfred Fessard, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.}, author = {Gheusi, Gilles and Cremer, Harold and McLean, Heather and Chazal, Genevi\~{A}¨ve and Vincent, Jean-Didier and Lledo, Pierre-Marie}, citeulike-article-id = {489951}, citeulike-linkout-0 = {http://www.pnas.org/content/97/4/1823.abstract}, citeulike-linkout-1 = {http://www.pnas.org/content/97/4/1823.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/10677540}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=10677540}, comment = {Good olfactory sensitivity, discrimination, and learning/memory paradigms.}, day = {15}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {adult, discrimination, learning, memory, mouse, ng, ob, olfactory, psancam, sensitivity}, month = {February}, number = {4}, pages = {1823--1828}, posted-at = {2006-02-02 20:22:00}, priority = {2}, title = {Importance of newly generated neurons in the adult olfactory bulb for odor discrimination}, url = {http://www.pnas.org/content/97/4/1823.abstract}, volume = {97}, year = {2000} }

TY - JOUR ID - citeulike:489951 L3 - citeulike-article-id:489951 N2 - In adult rodents, neurons are continually generated in the subventricular zone of the forebrain, from where they migrate tangentially toward the olfactory bulb, the only known target for these neuronal precursors. Within the main olfactory bulb, they ascend radially into the granule and periglomerular cell layers, where they differentiate mainly into local interneurons. The functional consequences of this permanent generation and integration of new neurons into existing circuits are unknown. To address this question, we used neural cell adhesion molecule-deficient mice that have documented deficits in the migration of olfactory-bulb neuron precursors, leading to about 40% size reduction of this structure. Our anatomical study reveals that this reduction is restricted to the granule cell layer, a structure that contains exclusively γ-aminobutyric acid (GABA)ergic interneurons. Furthermore, mutant mice were subjected to experiments designed to examine the behavioral consequences of such anatomical alteration. We found that the specific reduction in the newly generated interneuron population resulted in an impairment of discrimination between odors. In contrast, both the detection thresholds for odors and short-term olfactory memory were unaltered, demonstrating that a critical number of bulbar granule cells is crucial only for odor discrimination but not for general olfactory functions. IS - 4 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 AD - Centre National de la Recherche Scientifique, Institut Alfred Fessard, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France. EP - 1828 TI - Importance of newly generated neurons in the adult olfactory bulb for odor discrimination VL - 97 SP - 1823 KW - adult KW - discrimination KW - learning KW - memory KW - mouse KW - ng KW - ob KW - olfactory KW - psancam KW - sensitivity N1 - Good olfactory sensitivity, discrimination, and learning/memory paradigms. AU - Gheusi, Gilles AU - Cremer, Harold AU - McLean, Heather AU - Chazal, Geneviève AU - Vincent, Jean-Didier AU - Lledo, Pierre-Marie PY - 2000/02/15/ UR - http://www.pnas.org/content/97/4/1823.abstract ER -