Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Export

@article{citeulike:597763, abstract = {The potential role of doublecortin (Dcx), encoding a microtubule-associated protein, in brain development has remained controversial. Humans with mutations show profound alterations in cortical lamination, whereas in mouse, RNAi-mediated knockdown but not germline knockout shows abnormal positioning of cortical neurons. Here, we report that the doublecortin-like kinase (Dclk) gene functions in a partially redundant pathway with Dcx in the formation of axonal projections across the midline and migration of cortical neurons. Dosage-dependent genetic effects were observed in both interhemispheric connectivity and migration of cortically and subcortically derived neurons. Surprisingly, RNAi-mediated knockdown of either gene results in similar migration defects. These results indicate the Dcx microtubule-associated protein family is required for proper neuronal migration and axonal wiring.}, address = {Neurogenetics Laboratory, Department of Neurosciences, University of California, San Diego, La Jolla, California 93093, USA.}, author = {Koizumi, H. and Tanaka, T. and Gleeson, J. G.}, citeulike-article-id = {597763}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2005.10.040}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16387639}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16387639}, day = {5}, doi = {10.1016/j.neuron.2005.10.040}, issn = {0896-6273}, journal = {Neuron}, keywords = {dcx, migration, mouse, ng}, month = {January}, number = {1}, pages = {55--66}, posted-at = {2006-04-24 14:12:45}, priority = {2}, title = {Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration.}, url = {http://dx.doi.org/10.1016/j.neuron.2005.10.040}, volume = {49}, year = {2006} }

TY - JOUR ID - citeulike:597763 L3 - citeulike-article-id:597763 N2 - The potential role of doublecortin (Dcx), encoding a microtubule-associated protein, in brain development has remained controversial. Humans with mutations show profound alterations in cortical lamination, whereas in mouse, RNAi-mediated knockdown but not germline knockout shows abnormal positioning of cortical neurons. Here, we report that the doublecortin-like kinase (Dclk) gene functions in a partially redundant pathway with Dcx in the formation of axonal projections across the midline and migration of cortical neurons. Dosage-dependent genetic effects were observed in both interhemispheric connectivity and migration of cortically and subcortically derived neurons. Surprisingly, RNAi-mediated knockdown of either gene results in similar migration defects. These results indicate the Dcx microtubule-associated protein family is required for proper neuronal migration and axonal wiring. IS - 1 JF - Neuron SN - 0896-6273 AD - Neurogenetics Laboratory, Department of Neurosciences, University of California, San Diego, La Jolla, California 93093, USA. EP - 66 TI - Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. VL - 49 SP - 55 KW - dcx KW - migration KW - mouse KW - ng AU - Koizumi, H AU - Tanaka, T AU - Gleeson, JG PY - 2006/01/05/ UR - http://dx.doi.org/10.1016/j.neuron.2005.10.040 ER -