Neurogenesis in the adult is involved in the formation of trace memories. Export

@article{citeulike:666294, abstract = {The vertebrate brain continues to produce new neurons throughout life. In the rat hippocampus, several thousand are produced each day, many of which die within weeks. Associative learning can enhance their survival; however, until now it was unknown whether new neurons are involved in memory formation. Here we show that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time. A similar reduction did not affect learning when the same stimuli are not separated in time, a task that is hippocampal-independent. The reduction in neurogenesis did not induce death of mature hippocampal neurons or permanently alter neurophysiological properties of the CA1 region, such as long-term potentiation. Moreover, recovery of cell production was associated with the ability to acquire trace memories. These results indicate that newly generated neurons in the adult are not only affected by the formation of a hippocampal-dependent memory, but also participate in it.}, address = {Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA. shors@rci.rutgers.edu}, author = {Shors, T. J. and Miesegaes, G. and Beylin, A. and Zhao, M. and Rydel, T. and Gould, E.}, citeulike-article-id = {666294}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/35066584}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11268214}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11268214}, day = {15}, doi = {10.1038/35066584}, issn = {0028-0836}, journal = {Nature}, keywords = {ablation, adult, dg, mam, ng, rat, traceeyeblinkconditioning}, month = {March}, number = {6826}, pages = {372--376}, posted-at = {2006-05-23 16:37:04}, priority = {2}, title = {Neurogenesis in the adult is involved in the formation of trace memories.}, url = {http://dx.doi.org/10.1038/35066584}, volume = {410}, year = {2001} }

TY - JOUR ID - citeulike:666294 L3 - citeulike-article-id:666294 N2 - The vertebrate brain continues to produce new neurons throughout life. In the rat hippocampus, several thousand are produced each day, many of which die within weeks. Associative learning can enhance their survival; however, until now it was unknown whether new neurons are involved in memory formation. Here we show that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time. A similar reduction did not affect learning when the same stimuli are not separated in time, a task that is hippocampal-independent. The reduction in neurogenesis did not induce death of mature hippocampal neurons or permanently alter neurophysiological properties of the CA1 region, such as long-term potentiation. Moreover, recovery of cell production was associated with the ability to acquire trace memories. These results indicate that newly generated neurons in the adult are not only affected by the formation of a hippocampal-dependent memory, but also participate in it. IS - 6826 JF - Nature SN - 0028-0836 AD - Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA. shors@rci.rutgers.edu EP - 376 TI - Neurogenesis in the adult is involved in the formation of trace memories. VL - 410 SP - 372 KW - ablation KW - adult KW - dg KW - mam KW - ng KW - rat KW - traceeyeblinkconditioning AU - Shors, TJ AU - Miesegaes, G AU - Beylin, A AU - Zhao, M AU - Rydel, T AU - Gould, E PY - 2001/03/15/ UR - http://dx.doi.org/10.1038/35066584 ER -