Functional neurogenesis in the adult hippocampus Export

@article{citeulike:666325, abstract = {There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.}, address = {Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. vanpraag@salk.edu}, author = {van Praag, Henriette and Schinder, Alejandro F. and Christie, Brian R. and Toni, Nicolas and Palmer, Theo D. and Gage, Fred H.}, citeulike-article-id = {666325}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/4151030a}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/4151030a}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11875571}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11875571}, day = {28}, doi = {10.1038/4151030a}, issn = {0028-0836}, journal = {Nature}, keywords = {adult, dg, exercise, gfp, integration, mouse, ng}, month = {February}, number = {6875}, pages = {1030--1034}, posted-at = {2006-05-23 17:15:29}, priority = {2}, title = {Functional neurogenesis in the adult hippocampus}, url = {http://dx.doi.org/10.1038/4151030a}, volume = {415}, year = {2002} }

TY - JOUR ID - citeulike:666325 L3 - citeulike-article-id:666325 N2 - There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain. IS - 6875 JF - Nature SN - 0028-0836 AD - Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. vanpraag@salk.edu EP - 1034 TI - Functional neurogenesis in the adult hippocampus VL - 415 SP - 1030 KW - adult KW - dg KW - exercise KW - gfp KW - integration KW - mouse KW - ng AU - van Praag, Henriette AU - Schinder, Alejandro AU - Christie, Brian AU - Toni, Nicolas AU - Palmer, Theo AU - Gage, Fred PY - 2002/02/28/ UR - http://dx.doi.org/10.1038/4151030a ER -