Learning enhances adult neurogenesis in the hippocampal formation. Export

@article{citeulike:666331, abstract = {Thousands of hippocampal neurons are born in adulthood, suggesting that new cells could be important for hippocampal function. To determine whether hippocampus-dependent learning affects adult-generated neurons, we examined the fate of new cells labeled with the thymidine analog bromodeoxyuridine following specific behavioral tasks. Here we report that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus. In contrast, training on associative learning tasks that do not require the hippocampus did not alter the number of new cells. These findings indicate that adult-generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.}, address = {Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA.}, author = {Gould, E. and Beylin, A. and Tanapat, P. and Reeves, A. and Shors, T. J.}, citeulike-article-id = {666331}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/6365}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10195219}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10195219}, doi = {10.1038/6365}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {adult, dg, learning, ng, rat, traceeyeblinkconditioning, watermaze}, month = {March}, number = {3}, pages = {260--265}, posted-at = {2006-05-23 17:29:21}, priority = {2}, title = {Learning enhances adult neurogenesis in the hippocampal formation.}, url = {http://dx.doi.org/10.1038/6365}, volume = {2}, year = {1999} }

TY - JOUR ID - citeulike:666331 L3 - citeulike-article-id:666331 N2 - Thousands of hippocampal neurons are born in adulthood, suggesting that new cells could be important for hippocampal function. To determine whether hippocampus-dependent learning affects adult-generated neurons, we examined the fate of new cells labeled with the thymidine analog bromodeoxyuridine following specific behavioral tasks. Here we report that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus. In contrast, training on associative learning tasks that do not require the hippocampus did not alter the number of new cells. These findings indicate that adult-generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation. IS - 3 JF - Nat Neurosci SN - 1097-6256 AD - Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA. EP - 265 TI - Learning enhances adult neurogenesis in the hippocampal formation. VL - 2 SP - 260 KW - adult KW - dg KW - learning KW - ng KW - rat KW - traceeyeblinkconditioning KW - watermaze AU - Gould, E AU - Beylin, A AU - Tanapat, P AU - Reeves, A AU - Shors, TJ PY - 1999/03// UR - http://dx.doi.org/10.1038/6365 ER -