Atomoxetine for treatment of marijuana dependence: A report on the efficacy and high incidence of gastrointestinal adverse events in a pilot study Export

@article{citeulike:3771609, abstract = {Marijuana users consistently demonstrate impairments in attention, executive function and response inhibition, which resemble deficits seen in attention deficit hyperactivity disorder (ADHD). We hypothesized that targeting the cognitive deficits associated with chronic marijuana use through ADHD medications may help identify a therapeutic agent for marijuana dependence. Thirteen subjects participated in an 11-week open label study to determine the feasibility, safety and tolerability of atomoxetine for individuals seeking treatment for marijuana dependence. The Time-Line Follow-Back measured marijuana use 90 days prior to study entry (p-TLFB) and weekly during the study (s-TLFB) along with weekly qualitative urine drug screen (UDS). Marijuana dependent subjects taking atomoxetine experienced an inordinate number of gastrointestinal (GI) adverse events. Overall, 10 of 13 subjects (77\%) experienced a mild to moderate GI adverse event defined as nausea, vomiting, dyspepsia, and loose stools. Atomoxetine is of limited utility in the treatment of cannabis dependence and is associated with clinically significant GI adverse events.}, author = {Tirado, C. and Goldman, M. and Lynch, K. and Kampman, K. and Obrien, C.}, citeulike-article-id = {3771609}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.drugalcdep.2007.10.020}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0376871607004656}, day = {07}, doi = {10.1016/j.drugalcdep.2007.10.020}, issn = {03768716}, journal = {Drug and Alcohol Dependence}, keywords = {atomoxetine, cannabis, marijuana}, month = {January}, posted-at = {2008-12-10 23:34:16}, priority = {2}, title = {Atomoxetine for treatment of marijuana dependence: A report on the efficacy and high incidence of gastrointestinal adverse events in a pilot study}, url = {http://dx.doi.org/10.1016/j.drugalcdep.2007.10.020}, year = {2008} }

TY - JOUR ID - citeulike:3771609 L3 - citeulike-article-id:3771609 N2 - Marijuana users consistently demonstrate impairments in attention, executive function and response inhibition, which resemble deficits seen in attention deficit hyperactivity disorder (ADHD). We hypothesized that targeting the cognitive deficits associated with chronic marijuana use through ADHD medications may help identify a therapeutic agent for marijuana dependence. Thirteen subjects participated in an 11-week open label study to determine the feasibility, safety and tolerability of atomoxetine for individuals seeking treatment for marijuana dependence. The Time-Line Follow-Back measured marijuana use 90 days prior to study entry (p-TLFB) and weekly during the study (s-TLFB) along with weekly qualitative urine drug screen (UDS). Marijuana dependent subjects taking atomoxetine experienced an inordinate number of gastrointestinal (GI) adverse events. Overall, 10 of 13 subjects (77%) experienced a mild to moderate GI adverse event defined as nausea, vomiting, dyspepsia, and loose stools. Atomoxetine is of limited utility in the treatment of cannabis dependence and is associated with clinically significant GI adverse events. JF - Drug and Alcohol Dependence SN - 03768716 TI - Atomoxetine for treatment of marijuana dependence: A report on the efficacy and high incidence of gastrointestinal adverse events in a pilot study KW - atomoxetine KW - cannabis KW - marijuana AU - Tirado, C AU - Goldman, M AU - Lynch, K AU - Kampman, K AU - Obrien, C PY - 2008/01/07/ UR - http://dx.doi.org/10.1016/j.drugalcdep.2007.10.020 ER -