Factors triggering abolishment of benzodiazepines effects in the Four-Plate Test--retest in mice. Export

@article{citeulike:3771923, abstract = {Abolishment of anxiolytic-like effects of diazepam occurs during re-exposure to some animal tests of anxiety. We investigated the loss of anxiolytic-like effects of diazepam during Trial 2 on previously undrugged mice, namely one-trial tolerance (OTT). Swiss mice were subjected to 1) Four-Plate Test (FPT) without punishments in Trial 1 or 2) FPT without punishments in both Trials or 3) FPT with spatial modifications in Trial 1 or 4) Elevated Plus Maze (EPM), then 24 h later to FPT, with saline, diazepam (1 mg/kg) or DOI (1 mg/kg). Removing punishments in Trial 1 does not counteract the effect reduction of diazepam in Trial 2, but spatial modifications of the aversive environment. Previous exposure to EPM does not trigger a loss of efficacy of diazepam in FPT. Electric punishments do not trigger OTT to benzodiazepines; whilst knowledge of the environment seems to be responsible for this phenomenon. FPT may be useful to study OTT because punishments potentate OTT in this model of anxiety.}, author = {Petit-Demouli\`{e}re, B. and Hasco\"{e}t, M. and Bourin, M.}, citeulike-article-id = {3771923}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.euroneuro.2007.04.006}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0924977X07000971}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17544259}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17544259}, doi = {10.1016/j.euroneuro.2007.04.006}, issn = {0924-977X}, journal = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, keywords = {4-iodo-25-dimethoxy-phenylisopropylamine, anxiety, diazepam, doi}, month = {January}, number = {1}, pages = {41--47}, posted-at = {2008-12-11 00:15:04}, priority = {2}, title = {Factors triggering abolishment of benzodiazepines effects in the Four-Plate Test--retest in mice.}, url = {http://dx.doi.org/10.1016/j.euroneuro.2007.04.006}, volume = {18}, year = {2008} }

TY - JOUR ID - citeulike:3771923 L3 - citeulike-article-id:3771923 N2 - Abolishment of anxiolytic-like effects of diazepam occurs during re-exposure to some animal tests of anxiety. We investigated the loss of anxiolytic-like effects of diazepam during Trial 2 on previously undrugged mice, namely one-trial tolerance (OTT). Swiss mice were subjected to 1) Four-Plate Test (FPT) without punishments in Trial 1 or 2) FPT without punishments in both Trials or 3) FPT with spatial modifications in Trial 1 or 4) Elevated Plus Maze (EPM), then 24 h later to FPT, with saline, diazepam (1 mg/kg) or DOI (1 mg/kg). Removing punishments in Trial 1 does not counteract the effect reduction of diazepam in Trial 2, but spatial modifications of the aversive environment. Previous exposure to EPM does not trigger a loss of efficacy of diazepam in FPT. Electric punishments do not trigger OTT to benzodiazepines; whilst knowledge of the environment seems to be responsible for this phenomenon. FPT may be useful to study OTT because punishments potentate OTT in this model of anxiety. IS - 1 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology SN - 0924-977X EP - 47 TI - Factors triggering abolishment of benzodiazepines effects in the Four-Plate Test--retest in mice. VL - 18 SP - 41 KW - 4-iodo-25-dimethoxy-phenylisopropylamine KW - anxiety KW - diazepam KW - doi AU - Petit-Demoulière, B AU - Hascoët, M AU - Bourin, M PY - 2008/01// UR - http://dx.doi.org/10.1016/j.euroneuro.2007.04.006 ER -