Ginseng pharmacology Multiple constituents and multiple actions Export

@article{citeulike:3798527, abstract = {Ginseng is a highly valued herb in the Far East and has gained popularity in the West during the last decade. There is extensive literature on the beneficial effects of ginseng and its constituents. The major active components of ginseng are ginsenosides, a diverse group of steroidal saponins, which demonstrate the ability to target a myriad of tissues, producing an array of pharmacological responses. However, many mechanisms of ginsenoside activity still remain unknown. Since ginsenosides and other constituents of ginseng produce effects that are different from one another, and a single ginsenoside initiates multiple actions in the same tissue, the overall pharmacology of ginseng is complex. The ability of ginsenosides to independently target multireceptor systems at the plasma membrane, as well as to activate intracellular steroid receptors, may explain some pharmacological effects. This commentary aims to review selected effects of ginseng and ginsenosides and describe their possible modes of action. Structural variability of ginsenosides, structural and functional relationship to steroids, and potential targets of action are discussed.}, author = {Attele, A.}, citeulike-article-id = {3798527}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0006-2952(99)00212-9}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0006-2952(99)00212-9}, day = {1}, doi = {10.1016/S0006-2952(99)00212-9}, issn = {00062952}, journal = {Biochemical Pharmacology}, keywords = {ethnobotany, ethnopharmacology, ginseng, ginsenosides, panax\_ginseng}, month = {December}, number = {11}, pages = {1685--1693}, posted-at = {2008-12-16 18:10:57}, priority = {2}, title = {Ginseng pharmacology Multiple constituents and multiple actions}, url = {http://dx.doi.org/10.1016/S0006-2952(99)00212-9}, volume = {58}, year = {1999} }

TY - JOUR ID - citeulike:3798527 L3 - citeulike-article-id:3798527 N2 - Ginseng is a highly valued herb in the Far East and has gained popularity in the West during the last decade. There is extensive literature on the beneficial effects of ginseng and its constituents. The major active components of ginseng are ginsenosides, a diverse group of steroidal saponins, which demonstrate the ability to target a myriad of tissues, producing an array of pharmacological responses. However, many mechanisms of ginsenoside activity still remain unknown. Since ginsenosides and other constituents of ginseng produce effects that are different from one another, and a single ginsenoside initiates multiple actions in the same tissue, the overall pharmacology of ginseng is complex. The ability of ginsenosides to independently target multireceptor systems at the plasma membrane, as well as to activate intracellular steroid receptors, may explain some pharmacological effects. This commentary aims to review selected effects of ginseng and ginsenosides and describe their possible modes of action. Structural variability of ginsenosides, structural and functional relationship to steroids, and potential targets of action are discussed. IS - 11 JF - Biochemical Pharmacology SN - 00062952 EP - 1693 TI - Ginseng pharmacology Multiple constituents and multiple actions VL - 58 SP - 1685 KW - ethnobotany KW - ethnopharmacology KW - ginseng KW - ginsenosides KW - panax_ginseng AU - Attele, A PY - 1999/12/01/ UR - http://dx.doi.org/10.1016/S0006-2952(99)00212-9 ER -