Possible Differential Induction of Phase 2 Enzyme and Antioxidant Pathways by American Ginseng, Panax quinquefolius Export

@article{citeulike:3798531, abstract = {Human immunodeficiency virus (HIV)-infected patients often take herbal medicines, which may interact with antiretrovirals. American ginseng induces phase 2 and antioxidant enzymes in vitro and might increase the clearance of zidovudine and/or enhance antioxidant activity. Ten healthy volunteers received 300 mg of zidovudine orally before and after 2 weeks of treatment with a ginsenoside-enriched American ginseng extract 200 mg twice daily. This ginseng extract induced the phase 2 enzyme quinone reductase with an average concentration of doubling of enzyme activity of 190 {micro}g/mL. Total ginsenoside content was 8.5 {+/-} 0.5\%. Pharmacokinetic profiles of zidovudine and oxidative stress marker concentrations were measured post-zidovudine dose. American ginseng does not significantly affect the formation clearance of zidovudine to its glucuronide (ratio post- to pre-American ginseng = 1.17; 90\% confidence interval: 0.95-1.45; P = .21), total clearance (ratio = 0.97; 0.82-1.14; P = .70), or plasma zidovudine AUC0-8 (ratio = 1.03; 0.87-1.21; P = .77). Oxidative stress biomarkers are reduced post-American ginseng (F2-isoprostane ratio = 0.79; 0.72-0.86; P < .001; 8-hydroxy-deoxyguanosine ratio = 0.74; 0.59-0.92; P = .02). Two weeks of American ginseng does not alter zidovudine pharmacokinetics but reduces oxidative stress markers. 10.1177/0091270008314252}, author = {Lee, Lawrence S. and Wise, Stephen D. and Chan, Clark and Parsons, Teresa L. and Flexner, Charles and Lietman, Paul S.}, citeulike-article-id = {3798531}, citeulike-linkout-0 = {http://dx.doi.org/10.1177/0091270008314252}, citeulike-linkout-1 = {http://jcp.sagepub.com/cgi/content/abstract/48/5/599}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18319359}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18319359}, day = {1}, doi = {10.1177/0091270008314252}, journal = {J Clin Pharmacol}, keywords = {antioxidant, ethnopharmacology, ginseng, ginsenosides, panax\_quinquefolius}, month = {May}, number = {5}, pages = {599--609}, posted-at = {2008-12-16 18:15:39}, priority = {2}, title = {Possible Differential Induction of Phase 2 Enzyme and Antioxidant Pathways by American Ginseng, Panax quinquefolius}, url = {http://dx.doi.org/10.1177/0091270008314252}, volume = {48}, year = {2008} }

TY - JOUR ID - citeulike:3798531 L3 - citeulike-article-id:3798531 N2 - Human immunodeficiency virus (HIV)-infected patients often take herbal medicines, which may interact with antiretrovirals. American ginseng induces phase 2 and antioxidant enzymes in vitro and might increase the clearance of zidovudine and/or enhance antioxidant activity. Ten healthy volunteers received 300 mg of zidovudine orally before and after 2 weeks of treatment with a ginsenoside-enriched American ginseng extract 200 mg twice daily. This ginseng extract induced the phase 2 enzyme quinone reductase with an average concentration of doubling of enzyme activity of 190 {micro}g/mL. Total ginsenoside content was 8.5 {+/-} 0.5%. Pharmacokinetic profiles of zidovudine and oxidative stress marker concentrations were measured post-zidovudine dose. American ginseng does not significantly affect the formation clearance of zidovudine to its glucuronide (ratio post- to pre-American ginseng = 1.17; 90% confidence interval: 0.95-1.45; P = .21), total clearance (ratio = 0.97; 0.82-1.14; P = .70), or plasma zidovudine AUC0-8 (ratio = 1.03; 0.87-1.21; P = .77). Oxidative stress biomarkers are reduced post-American ginseng (F2-isoprostane ratio = 0.79; 0.72-0.86; P < .001; 8-hydroxy-deoxyguanosine ratio = 0.74; 0.59-0.92; P = .02). Two weeks of American ginseng does not alter zidovudine pharmacokinetics but reduces oxidative stress markers. 10.1177/0091270008314252 IS - 5 JF - J Clin Pharmacol EP - 609 TI - Possible Differential Induction of Phase 2 Enzyme and Antioxidant Pathways by American Ginseng, Panax quinquefolius VL - 48 SP - 599 KW - antioxidant KW - ethnopharmacology KW - ginseng KW - ginsenosides KW - panax_quinquefolius AU - Lee, Lawrence AU - Wise, Stephen AU - Chan, Clark AU - Parsons, Teresa AU - Flexner, Charles AU - Lietman, Paul PY - 2008/05/01/ UR - http://dx.doi.org/10.1177/0091270008314252 ER -