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Modelling 'evo-devo' with RNA. Export

by: W. Fontana
Bioessays, Vol. 24, No. 12. (December 2002), pp. 1164-1177.

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neutralnetworks rna

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The folding of RNA sequences into secondary structures is a simple yet biophysically grounded model of a genotype-phenotype map. Its computational and mathematical analysis has uncovered a surprisingly rich statistical structure characterized by shape space covering, neutral networks and plastogenetic congruence. I review these concepts and discuss their evolutionary implications.


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