Neutral evolution of mutational robustness Export

@article{citeulike:202232, abstract = {We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population\^{a}€™s limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network\^{a}€™s adjacency matrix. Moreover, the average number of neutral mutant neighbors per individual is given by the matrix spectral radius. These results quantify the extent to which populations evolve mutational robustness\^{a}€”the insensitivity of the phenotype to mutations\^{a}€”and thus reduce genetic load. Because the average neutrality is independent of evolutionary parameters\^{a}€”such as mutation rate, population size, and selective advantage\^{a}€”one can infer global statistics of neutral network topology by using simple population data available from or evolution. Populations evolving on neutral networks of RNA secondary structures show excellent agreement with our theoretical predictions.}, address = {Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA.}, author = {van Nimwegen, Erik and Crutchfield, James P. and Huynen, Martijn}, booktitle = {Proceedings of the National Academy of Sciences of the United States of America}, citeulike-article-id = {202232}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.96.17.9716}, citeulike-linkout-1 = {http://www.pnas.org/content/96/17/9716.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/96/17/9716.full.pdf}, citeulike-linkout-3 = {http://www.pnas.org/cgi/content/abstract/96/17/9716}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/10449760}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=10449760}, day = {17}, doi = {10.1073/pnas.96.17.9716}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {mutationalrobustness, neutralnetworks}, month = {August}, number = {17}, pages = {9716--9720}, posted-at = {2005-05-18 01:42:09}, priority = {2}, title = {Neutral evolution of mutational robustness}, url = {http://dx.doi.org/10.1073/pnas.96.17.9716}, volume = {96}, year = {1999} }

TY - JOUR ID - citeulike:202232 L3 - citeulike-article-id:202232 N2 - We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population’s limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network’s adjacency matrix. Moreover, the average number of neutral mutant neighbors per individual is given by the matrix spectral radius. These results quantify the extent to which populations evolve mutational robustness—the insensitivity of the phenotype to mutations—and thus reduce genetic load. Because the average neutrality is independent of evolutionary parameters—such as mutation rate, population size, and selective advantage—one can infer global statistics of neutral network topology by using simple population data available from or evolution. Populations evolving on neutral networks of RNA secondary structures show excellent agreement with our theoretical predictions. IS - 17 JF - Proc Natl Acad Sci U S A SN - 0027-8424 AD - Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA. EP - 9720 TI - Neutral evolution of mutational robustness VL - 96 T2 - Proceedings of the National Academy of Sciences of the United States of America SP - 9716 KW - mutationalrobustness KW - neutralnetworks AU - van Nimwegen, Erik AU - Crutchfield, James AU - Huynen, Martijn PY - 1999/08/17/ UR - http://dx.doi.org/10.1073/pnas.96.17.9716 ER -