Exploring the immunology of parasitism ? from surface antigens to the hygiene hypothesis Export

@article{citeulike:4635116, abstract = {Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured. The molecular revolution defined key nematode surface and secreted antigens, and identified candidate immunomodulators that are likely to underpin parasites' success in eluding immune attack. The immunological advances in defining cytokine networks, lymphocyte subsets and innate cell recognition have also made a huge impact on our understanding of helminth infections. Most recently, the ideas of regulatory immune cells, in particular the regulatory T cell, have again overturned older thinking, but also may explain immune hyporesponsiveness observed in chronic helminth diseases, as well as the link to reduced allergic reactions observed in human and animal infections. The review concludes with a forward look to where we may make future advances towards the final eradication of helminth diseases.}, author = {Maizels, R. M.}, citeulike-article-id = {4635116}, citeulike-linkout-0 = {http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=5595416}, citeulike-linkout-1 = {http://dx.doi.org/10.1017/S0031182009006106}, doi = {10.1017/S0031182009006106}, journal = {Parasitology}, keywords = {allergy, cuticle, helminth, immunity, nematode, pathology}, number = {12}, pages = {1549--1564}, posted-at = {2009-10-31 11:20:32}, priority = {2}, title = {Exploring the immunology of parasitism ? from surface antigens to the hygiene hypothesis}, url = {http://dx.doi.org/10.1017/S0031182009006106}, volume = {136}, year = {2009} }

TY - JOUR ID - citeulike:4635116 L3 - citeulike-article-id:4635116 N2 - Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured. The molecular revolution defined key nematode surface and secreted antigens, and identified candidate immunomodulators that are likely to underpin parasites' success in eluding immune attack. The immunological advances in defining cytokine networks, lymphocyte subsets and innate cell recognition have also made a huge impact on our understanding of helminth infections. Most recently, the ideas of regulatory immune cells, in particular the regulatory T cell, have again overturned older thinking, but also may explain immune hyporesponsiveness observed in chronic helminth diseases, as well as the link to reduced allergic reactions observed in human and animal infections. The review concludes with a forward look to where we may make future advances towards the final eradication of helminth diseases. IS - 12 JF - Parasitology EP - 1564 TI - Exploring the immunology of parasitism ? from surface antigens to the hygiene hypothesis VL - 136 SP - 1549 KW - allergy KW - cuticle KW - helminth KW - immunity KW - nematode KW - pathology AU - Maizels, RM PY - 2009/// UR - http://dx.doi.org/10.1017/S0031182009006106 ER -