Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver Export

@article{citeulike:4791659, abstract = {Prostaglandin (PG) E 2 is considered to participate in the storage of fat in adipocytes and hepatocytes, but roles of group IVA phospholipase A 2 (PLA 2 ), a key PLA 2 isozyme in the arachidonic acid cascade, remain unclear. The present study examined the possible involvement of the enzyme using group IVA PLA 2 -deficient mice (C57BL/6 background, 22 weeks of age) fed a normal diet (5.3\% fat). The ratio of epididymal fat pad weight to body weight was significantly reduced in group IVA PLA 2 -deficient mice compared to wild-type mice. Histological analysis revealed that in group IVA PLA 2 -deficient mice, the adipocytes were smaller, and hepatocytes bearing cytoplasmic vacuolation were scarce. Hepatic triglyceride content and the serum levels of PGE 2 in the deficient mice were also lower. However, there was no difference in the serum levels of insulin, glucose, non-esterified free fatty acid, or total cholesterol between the deficient and wild-type mice. Our findings suggest that group IVA PLA 2 is involved in the storage of lipids in the adipose tissue and liver and in determining circulating PGE 2 levels.}, author = {Ii, H. and Hatakeyama, S. and Tsutsumi, K. and Sato, T. and Akiba, S.}, citeulike-article-id = {4791659}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.prostaglandins.2007.12.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1098882308000166}, doi = {10.1016/j.prostaglandins.2007.12.002}, issn = {10988823}, journal = {Prostaglandins \& Other Lipid Mediators}, keywords = {a2, phospholipase, prostaglandin, tg, triglyceride}, month = {June}, number = {1-4}, pages = {12--17}, posted-at = {2009-06-10 00:16:46}, priority = {2}, title = {Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver}, url = {http://dx.doi.org/10.1016/j.prostaglandins.2007.12.002}, volume = {86}, year = {2008} }

TY - JOUR ID - citeulike:4791659 L3 - citeulike-article-id:4791659 N2 - Prostaglandin (PG) E 2 is considered to participate in the storage of fat in adipocytes and hepatocytes, but roles of group IVA phospholipase A 2 (PLA 2 ), a key PLA 2 isozyme in the arachidonic acid cascade, remain unclear. The present study examined the possible involvement of the enzyme using group IVA PLA 2 -deficient mice (C57BL/6 background, 22 weeks of age) fed a normal diet (5.3% fat). The ratio of epididymal fat pad weight to body weight was significantly reduced in group IVA PLA 2 -deficient mice compared to wild-type mice. Histological analysis revealed that in group IVA PLA 2 -deficient mice, the adipocytes were smaller, and hepatocytes bearing cytoplasmic vacuolation were scarce. Hepatic triglyceride content and the serum levels of PGE 2 in the deficient mice were also lower. However, there was no difference in the serum levels of insulin, glucose, non-esterified free fatty acid, or total cholesterol between the deficient and wild-type mice. Our findings suggest that group IVA PLA 2 is involved in the storage of lipids in the adipose tissue and liver and in determining circulating PGE 2 levels. IS - 1-4 JF - Prostaglandins & Other Lipid Mediators SN - 10988823 EP - 17 TI - Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver VL - 86 SP - 12 KW - a2 KW - phospholipase KW - prostaglandin KW - tg KW - triglyceride AU - Ii, H AU - Hatakeyama, S AU - Tsutsumi, K AU - Sato, T AU - Akiba, S PY - 2008/06// UR - http://dx.doi.org/10.1016/j.prostaglandins.2007.12.002 ER -