An attempt to define allergen-specific molecular surface features: a bioinformatic approach Export

@article{citeulike:405427, abstract = {Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface of diverse allergens may reveal common structural features which might enable them to be recognized as Th2-inducing antigens by cells of the innate immune system. We have therefore used the ConSurf server to search for allergen-specific motifs. This has enabled us to identify residue conservation patterns in the homologues of Ara t 8 (plant profilin), Act c 1 (actinidin), Bet v 1 (plant pathogenesis-related protein) and Ves v 5 (venom allergen). The results demonstrate the presence of allergen-specific patches consisting of an unusually high proportion of surface-exposed hydrophobic residues. The patches that have been identified may represent molecular patterns recognizable by cells of the innate immune system. Contact: farouk.shakib@nottingham.ac.uk Supplementary Information: http://www.nottingham.ac.uk/immunology/research/BI}, author = {Furmonaviciene, Ruta and Sutton, Brian J. and Glaser, Fabian and Laughton, Charlie A. and Jones, Nick and Sewell, Herb F. and Shakib, Farouk}, citeulike-article-id = {405427}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bioinformatics/bti700}, citeulike-linkout-1 = {http://bioinformatics.oxfordjournals.org/cgi/content/abstract/21/23/4201}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16204345}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16204345}, day = {1}, doi = {10.1093/bioinformatics/bti700}, journal = {Bioinformatics}, keywords = {allergy, protein-structure, proteinrecognition}, month = {December}, number = {23}, pages = {4201--4204}, posted-at = {2005-11-23 08:25:09}, priority = {2}, title = {An attempt to define allergen-specific molecular surface features: a bioinformatic approach}, url = {http://dx.doi.org/10.1093/bioinformatics/bti700}, volume = {21}, year = {2005} }

TY - JOUR ID - citeulike:405427 L3 - citeulike-article-id:405427 N2 - Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface of diverse allergens may reveal common structural features which might enable them to be recognized as Th2-inducing antigens by cells of the innate immune system. We have therefore used the ConSurf server to search for allergen-specific motifs. This has enabled us to identify residue conservation patterns in the homologues of Ara t 8 (plant profilin), Act c 1 (actinidin), Bet v 1 (plant pathogenesis-related protein) and Ves v 5 (venom allergen). The results demonstrate the presence of allergen-specific patches consisting of an unusually high proportion of surface-exposed hydrophobic residues. The patches that have been identified may represent molecular patterns recognizable by cells of the innate immune system. Contact: farouk.shakib@nottingham.ac.uk Supplementary Information: http://www.nottingham.ac.uk/immunology/research/BI IS - 23 JF - Bioinformatics EP - 4204 TI - An attempt to define allergen-specific molecular surface features: a bioinformatic approach VL - 21 SP - 4201 KW - allergy KW - protein-structure KW - proteinrecognition AU - Furmonaviciene, Ruta AU - Sutton, Brian AU - Glaser, Fabian AU - Laughton, Charlie AU - Jones, Nick AU - Sewell, Herb AU - Shakib, Farouk PY - 2005/12/01/ UR - http://dx.doi.org/10.1093/bioinformatics/bti700 ER -