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Nature biotechnology, Vol. 25, No. 8. (01 August 2007), pp. 883-885, doi:10.1038/nbt0807-883 Key: citeulike:1544641
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Computational prediction of gene structure is crucial for interpreting genomic sequences. But how do the algorithms involved work and how accurate are they? Gene-prediction programs are used primarily to annotate large, contiguous sequences generated by whole-genome sequencing. Most programs used for this purpose aim to predict the complete exon-intron structures of the protein-encoding portions of transcripts (open reading frames or ORFs).
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