All is not Toll: new pathways in DNA recognition Export

@article{citeulike:6087263, abstract = {Immunological defense depends on the ability of the innate immune system to recognize invading microbes as foreign and thus eliminate them. The Toll-like receptors (TLRs) help detect foreign invaders by sensing various pathogen-associated molecules, including microbial RNA and DNA. At present, it is unclear whether and how the immune system distinguishes between microbial and self nucleic acids, as host-derived RNA and DNA also stimulate TLRs. In addition, recent studies have revealed the existence of TLR-independent pathways that are activated in response to microbial and host nucleic acids. 10.1084/jem.20052191}, author = {Wagner, Hermann and Bauer, Stefan}, citeulike-article-id = {6087263}, citeulike-linkout-0 = {http://dx.doi.org/10.1084/jem.20052191}, citeulike-linkout-1 = {http://jem.rupress.org/content/203/2/265.abstract}, citeulike-linkout-2 = {http://jem.rupress.org/content/203/2/265.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/16446382}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=16446382}, day = {21}, doi = {10.1084/jem.20052191}, journal = {J. Exp. Med.}, keywords = {z-dna}, month = {February}, number = {2}, pages = {265--268}, posted-at = {2009-11-09 08:04:40}, priority = {2}, title = {All is not Toll: new pathways in DNA recognition}, url = {http://dx.doi.org/10.1084/jem.20052191}, volume = {203}, year = {2006} }

TY - JOUR ID - citeulike:6087263 L3 - citeulike-article-id:6087263 N2 - Immunological defense depends on the ability of the innate immune system to recognize invading microbes as foreign and thus eliminate them. The Toll-like receptors (TLRs) help detect foreign invaders by sensing various pathogen-associated molecules, including microbial RNA and DNA. At present, it is unclear whether and how the immune system distinguishes between microbial and self nucleic acids, as host-derived RNA and DNA also stimulate TLRs. In addition, recent studies have revealed the existence of TLR-independent pathways that are activated in response to microbial and host nucleic acids. 10.1084/jem.20052191 IS - 2 JF - J. Exp. Med. EP - 268 TI - All is not Toll: new pathways in DNA recognition VL - 203 SP - 265 KW - z-dna AU - Wagner, Hermann AU - Bauer, Stefan PY - 2006/02/21/ UR - http://dx.doi.org/10.1084/jem.20052191 ER -