Protein Dynamism and Evolvability Export

@article{citeulike:4295654, abstract = {The traditional view that proteins possess absolute functional specificity and a single, fixed structure conflicts with their marked ability to adapt and evolve new functions and structures. We consider an alternative, "avant-garde view" in which proteins are conformationally dynamic and exhibit functional promiscuity. We surmise that these properties are the foundation stones of protein evolvability; they facilitate the divergence of new functions within existing folds and the evolution of entirely new folds. Packing modes of proteins also affect their evolvability, and poorly packed, disordered, and conformationally diverse proteins may exhibit high evolvability. This dynamic view of protein structure, function, and evolvability is extrapolated to describe hypothetical scenarios for the evolution of the early proteins and future research directions in the area of protein dynamism and evolution. 10.1126/science.1169375}, author = {Tokuriki, Nobuhiko and Tawfik, Dan S.}, citeulike-article-id = {4295654}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1169375}, citeulike-linkout-1 = {http://www.sciencemag.org/content/324/5924/203.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/324/5924/203.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/324/5924/203}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19359577}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19359577}, day = {10}, doi = {10.1126/science.1169375}, issn = {1095-9203}, journal = {Science}, keywords = {conformational\_flexibility, dynamics, evolution, function}, month = {April}, number = {5924}, pages = {203--207}, posted-at = {2009-11-07 16:29:11}, priority = {4}, title = {Protein Dynamism and Evolvability}, url = {http://dx.doi.org/10.1126/science.1169375}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4295654 L3 - citeulike-article-id:4295654 N2 - The traditional view that proteins possess absolute functional specificity and a single, fixed structure conflicts with their marked ability to adapt and evolve new functions and structures. We consider an alternative, "avant-garde view" in which proteins are conformationally dynamic and exhibit functional promiscuity. We surmise that these properties are the foundation stones of protein evolvability; they facilitate the divergence of new functions within existing folds and the evolution of entirely new folds. Packing modes of proteins also affect their evolvability, and poorly packed, disordered, and conformationally diverse proteins may exhibit high evolvability. This dynamic view of protein structure, function, and evolvability is extrapolated to describe hypothetical scenarios for the evolution of the early proteins and future research directions in the area of protein dynamism and evolution. 10.1126/science.1169375 IS - 5924 JF - Science SN - 1095-9203 EP - 207 TI - Protein Dynamism and Evolvability VL - 324 SP - 203 KW - conformational_flexibility KW - dynamics KW - evolution KW - function AU - Tokuriki, Nobuhiko AU - Tawfik, Dan PY - 2009/04/10/ UR - http://dx.doi.org/10.1126/science.1169375 ER -