Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. Export

@article{citeulike:233943, abstract = {Female transgenic FVB/N mice carrying the breast cancer gene HER-2/neu received epithalon (Ala-Glu-Asp-Gly) in a dose of 1 mg subcutaneously 5 times a week to from the 2nd month of life to death. Epithalon prolonged the average and maximum lifetimes of mice by 13.5 (p<0.05) and 13.9\%, respectively. The peptide prolonged the average lifetime of animals without neoplasms (by 34.2\%, p<0.05). Epithalon decelerated the development of age-related disturbances in reproductive activity and suppressed the formation of neoplasms. The peptide decreased the incidence of breast adenocarcinomas, lungs metastases (by 1.6 times, p<0.05), and multiple tumors (by 2 times). Epithalon 3.7-fold increased the number of mice without breast tumors (p<0.05), while the number of animals with 6 or more breast tumors decreased by 3 times (p<0.05). Epithalon prolonged the lifetime of mice with breast tumors by 1.4 times (p<0.05). These results indicate that Epithalon possesses geroprotective activity and inhibits breast carcinogenesis in transgenic mice, which is probably related to suppression of HER-2/neu expression.}, address = {Max Planck Institute for demographic Research of Society, Rostock, Germany.}, author = {Anisimov, V. N. and Khavinson, V. K. h. and Alimova, I. N. and Semchenko, A. V. and Yashin, A. I.}, citeulike-article-id = {233943}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12459848}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12459848}, issn = {0007-4888}, journal = {Bull Exp Biol Med}, keywords = {adenocarcinoma, aging, breast, epitalon, epithalon, mice}, month = {August}, number = {2}, pages = {187--190}, posted-at = {2005-06-22 01:26:07}, priority = {2}, title = {Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12459848}, volume = {134}, year = {2002} }

TY - JOUR ID - citeulike:233943 L3 - citeulike-article-id:233943 N2 - Female transgenic FVB/N mice carrying the breast cancer gene HER-2/neu received epithalon (Ala-Glu-Asp-Gly) in a dose of 1 mg subcutaneously 5 times a week to from the 2nd month of life to death. Epithalon prolonged the average and maximum lifetimes of mice by 13.5 (p<0.05) and 13.9%, respectively. The peptide prolonged the average lifetime of animals without neoplasms (by 34.2%, p<0.05). Epithalon decelerated the development of age-related disturbances in reproductive activity and suppressed the formation of neoplasms. The peptide decreased the incidence of breast adenocarcinomas, lungs metastases (by 1.6 times, p<0.05), and multiple tumors (by 2 times). Epithalon 3.7-fold increased the number of mice without breast tumors (p<0.05), while the number of animals with 6 or more breast tumors decreased by 3 times (p<0.05). Epithalon prolonged the lifetime of mice with breast tumors by 1.4 times (p<0.05). These results indicate that Epithalon possesses geroprotective activity and inhibits breast carcinogenesis in transgenic mice, which is probably related to suppression of HER-2/neu expression. IS - 2 JF - Bull Exp Biol Med SN - 0007-4888 AD - Max Planck Institute for demographic Research of Society, Rostock, Germany. EP - 190 TI - Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. VL - 134 SP - 187 KW - adenocarcinoma KW - aging KW - breast KW - epitalon KW - epithalon KW - mice AU - Anisimov, VN AU - Khavinson, VKh AU - Alimova, IN AU - Semchenko, AV AU - Yashin, AI PY - 2002/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/12459848 ER -