[Activation of ATP-sensitive K+-channels of cardiomyocytes by endogenous cardiopeptides] Export

@article{citeulike:235012, abstract = {The "patch-clamp" method was applied to rat ventricular cardiomyocytes to study the effect of endogenous cardiopeptides (a component of a cardiologic medicine "cardialin") on single K(+)-channel currents. It was noted that ATP-sensitive K(+)-channel activity increased only in the presence of 10(-8)-10(-6) mg.ml-1 peptide solution in the patch-clamp micropipette. To check up the suggestion that G-protein takes part in a direct reaction of K(+)-channel by external ligand we studied the effect of GTP-gamma-S (0.1 mM) in the presence of Mg2+ (1 mM) on the K(+)-channel in "run-down" state in the "inside-out" configuration. It was demonstrated experimentally that reactivation of the ATP-sensitive K(+)-channel develops in the presence of GTP-analogue.}, author = {Babenko, A. P. and Kazantseva, S. T. and Khavinson, V. K. h.}, citeulike-article-id = {235012}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/1421309}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=1421309}, issn = {0365-9615}, journal = {Biull Eksp Biol Med}, keywords = {cardyomyocytes, channels, peptides, potassium}, month = {July}, number = {7}, pages = {54--56}, posted-at = {2005-06-22 22:31:11}, priority = {2}, title = {[Activation of ATP-sensitive K+-channels of cardiomyocytes by endogenous cardiopeptides]}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1421309}, volume = {114}, year = {1992} }

TY - JOUR ID - citeulike:235012 L3 - citeulike-article-id:235012 N2 - The "patch-clamp" method was applied to rat ventricular cardiomyocytes to study the effect of endogenous cardiopeptides (a component of a cardiologic medicine "cardialin") on single K(+)-channel currents. It was noted that ATP-sensitive K(+)-channel activity increased only in the presence of 10(-8)-10(-6) mg.ml-1 peptide solution in the patch-clamp micropipette. To check up the suggestion that G-protein takes part in a direct reaction of K(+)-channel by external ligand we studied the effect of GTP-gamma-S (0.1 mM) in the presence of Mg2+ (1 mM) on the K(+)-channel in "run-down" state in the "inside-out" configuration. It was demonstrated experimentally that reactivation of the ATP-sensitive K(+)-channel develops in the presence of GTP-analogue. IS - 7 JF - Biull Eksp Biol Med SN - 0365-9615 EP - 56 TI - [Activation of ATP-sensitive K+-channels of cardiomyocytes by endogenous cardiopeptides] VL - 114 SP - 54 KW - cardyomyocytes KW - channels KW - peptides KW - potassium AU - Babenko, AP AU - Kazantseva, ST AU - Khavinson, VKh PY - 1992/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/1421309 ER -