[Effect of a drug isolated from the heart on the bioenergetics of cardiomyocytes in hypoxia and ischemia] Export

@article{citeulike:235016, abstract = {It has been established that cordialin inhibits selectively succinic acid oxidation and intensifies the exudation of a NADH2 substrate which is energetically more advantageous, and in this way has a favorable effect on energy metabolism, evidence of which is increase of the ATP content in the myocardium. Cordialin correction of the biologic energy of cardiomyocytes in hypoxia and ischemia prevents the accumulation of lipid drops in the cells of the peri-infarction zone, which reflects the high intensity of the processes of fatty acids beta-oxidation. As a result of this glycolysis activation is unnecessary (which is confirmed by high glycogen content, both of a qualitative and quantitative character, in the myocardium and low concentrations of glucose and lactate in the blood) and, consequently, the sequelae of acidosis are prevented.}, author = {Pavlenko, V. S. and Khlystov, V. V. and Andreeva, L. I. and Ershov, V. I. and Khavinson, V. K. h.}, citeulike-article-id = {235016}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/1408386}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=1408386}, issn = {0031-2991}, journal = {Patol Fiziol Eksp Ter}, keywords = {cardiomyocytes, heart, hypoxia, ischemia}, number = {2}, pages = {20--24}, posted-at = {2005-06-22 22:33:26}, priority = {2}, title = {[Effect of a drug isolated from the heart on the bioenergetics of cardiomyocytes in hypoxia and ischemia]}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1408386}, year = {1992} }

TY - JOUR ID - citeulike:235016 L3 - citeulike-article-id:235016 N2 - It has been established that cordialin inhibits selectively succinic acid oxidation and intensifies the exudation of a NADH2 substrate which is energetically more advantageous, and in this way has a favorable effect on energy metabolism, evidence of which is increase of the ATP content in the myocardium. Cordialin correction of the biologic energy of cardiomyocytes in hypoxia and ischemia prevents the accumulation of lipid drops in the cells of the peri-infarction zone, which reflects the high intensity of the processes of fatty acids beta-oxidation. As a result of this glycolysis activation is unnecessary (which is confirmed by high glycogen content, both of a qualitative and quantitative character, in the myocardium and low concentrations of glucose and lactate in the blood) and, consequently, the sequelae of acidosis are prevented. IS - 2 JF - Patol Fiziol Eksp Ter SN - 0031-2991 EP - 24 TI - [Effect of a drug isolated from the heart on the bioenergetics of cardiomyocytes in hypoxia and ischemia] SP - 20 KW - cardiomyocytes KW - heart KW - hypoxia KW - ischemia AU - Pavlenko, VS AU - Khlystov, VV AU - Andreeva, LI AU - Ershov, VI AU - Khavinson, VKh PY - 1992///r UR - http://view.ncbi.nlm.nih.gov/pubmed/1408386 ER -