Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. Export

@article{citeulike:235286, abstract = {The low-molecular-weight polypeptide factors were obtained from bovine thymus (TF), pineal gland (PF) and anterior hypothalamus (AHF). Both TF and PF administration enhanced the rejection of skin allograft and stimulated the immunological response to sheep erythrocytes in adult CBA mice. Treatment of CBA mice with AHF increased the graft survival and inhibited antibody formation to sheep erythrocytes. Chronic TF or PF administration decreased spontaneous tumor development and prolonged the life span of female C3H/Sn mice. Administration of AHF failed to influence the life span and the tumor incidence of female C3H/Sn mice. The role of immunity and hormonometabolic shifts in mechanisms of both aging and the age-associated increase in cancer incidence are discussed.}, author = {Anisimov, V. N. and Khavinson, V. K. and Morozov, V. G.}, citeulike-article-id = {235286}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/6752596}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=6752596}, issn = {0047-6374}, journal = {Mech Ageing Dev}, keywords = {aging, carcinogenesis, hypothalamus, immune, lifespan, mice, pineal\_gland, thymus, tumour}, month = {July}, number = {3}, pages = {245--258}, posted-at = {2005-06-23 10:34:42}, priority = {2}, title = {Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/6752596}, volume = {19}, year = {1982} }

TY - JOUR ID - citeulike:235286 L3 - citeulike-article-id:235286 N2 - The low-molecular-weight polypeptide factors were obtained from bovine thymus (TF), pineal gland (PF) and anterior hypothalamus (AHF). Both TF and PF administration enhanced the rejection of skin allograft and stimulated the immunological response to sheep erythrocytes in adult CBA mice. Treatment of CBA mice with AHF increased the graft survival and inhibited antibody formation to sheep erythrocytes. Chronic TF or PF administration decreased spontaneous tumor development and prolonged the life span of female C3H/Sn mice. Administration of AHF failed to influence the life span and the tumor incidence of female C3H/Sn mice. The role of immunity and hormonometabolic shifts in mechanisms of both aging and the age-associated increase in cancer incidence are discussed. IS - 3 JF - Mech Ageing Dev SN - 0047-6374 EP - 258 TI - Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. VL - 19 SP - 245 KW - aging KW - carcinogenesis KW - hypothalamus KW - immune KW - lifespan KW - mice KW - pineal_gland KW - thymus KW - tumour AU - Anisimov, VN AU - Khavinson, VK AU - Morozov, VG PY - 1982/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/6752596 ER -