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[Regulation of the functional activity of the stem cell precursors of granulo- and monopoiesis by polypeptide factors of the thymus and bone marrow] Export

Biull Eksp Biol Med, Vol. 93, No. 4. (April 1982), pp. 94-95.

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bone_marrow polypeptide_factors stem_cells thymus

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Effect of polypeptide thymic and bone marrow factors on functional activity of stem cells was studied with the use of two-layer agar system containing human bone marrow hemopoietic cells. Unlike bone marrow factor, thymic factor appreciably increased the cluster- and colony-forming abilities of cells - precursors of granulomonopoiesis. The results indicate that thymic and bone marrow factors regulate different stages of stem cell differentiation.


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