Association of tibia lead and blood lead with end-stage renal disease: a pilot study of African-Americans. Export

@article{citeulike:3422999, abstract = {The association between body lead burden and kidney disease remains controversial. Fifty-five African-American end-stage renal disease (ESRD) cases and 53 age- and sex-matched African-American controls without known renal disease were recruited from Tulane University-affiliated dialysis clinics and out-patient clinics, respectively. Blood lead was measured via atomic absorption spectrophotometry and tibia lead (a measure of body lead) was measured via (109)Cd-based K shell X-ray fluorescence. Median blood lead levels were significantly higher among ESRD cases (6 microg/dL) compared to their control counterparts (3 microg/dL; P<0.001). Although no participants had overt lead poisoning (blood lead > or = 25 microg/dL), seven cases but no controls had blood lead levels above 10 microg/dL (P=0.006). The median tibia lead level was 17 micrograms of lead per gram of bone mineral (microg/g) and 13 microg/g among ESRD cases and their control counterparts, respectively (P=0.134). Four ESRD cases (7\%), but no controls, had a tibia lead level above 40 microg/g (P=0.115) while a similar proportion of cases and controls had tibia lead between 20 and 39 microg/g (33\% and 32\%, respectively; P=0.726). After adjustment for potential confounders, the odds ratios of ESRD associated with a tibia lead > or = 20 microg/g and each four-fold higher tibia lead (e.g., 5-20 microg/g) were 1.55 (95\% CI: 0.55, 4.41) and 1.88 (95\% CI: 0.53, 6.68), respectively. These findings support the need for prospective cohort studies of body lead burden and renal disease progression.}, author = {Muntner, P. and Menke, A. and Batuman, V. and Rabito, F. A. and He, J. and Todd, A. C.}, citeulike-article-id = {3422999}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.envres.2007.04.001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17511982}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17511982}, doi = {10.1016/j.envres.2007.04.001}, issn = {0013-9351}, journal = {Environmental research}, keywords = {african\_american, kidney, lead, lead\_bone, renal, tibia}, month = {July}, number = {3}, pages = {396--401}, posted-at = {2009-10-22 20:18:12}, priority = {2}, title = {Association of tibia lead and blood lead with end-stage renal disease: a pilot study of African-Americans.}, url = {http://dx.doi.org/10.1016/j.envres.2007.04.001}, volume = {104}, year = {2007} }

TY - JOUR ID - citeulike:3422999 L3 - citeulike-article-id:3422999 N2 - The association between body lead burden and kidney disease remains controversial. Fifty-five African-American end-stage renal disease (ESRD) cases and 53 age- and sex-matched African-American controls without known renal disease were recruited from Tulane University-affiliated dialysis clinics and out-patient clinics, respectively. Blood lead was measured via atomic absorption spectrophotometry and tibia lead (a measure of body lead) was measured via (109)Cd-based K shell X-ray fluorescence. Median blood lead levels were significantly higher among ESRD cases (6 microg/dL) compared to their control counterparts (3 microg/dL; P<0.001). Although no participants had overt lead poisoning (blood lead > or = 25 microg/dL), seven cases but no controls had blood lead levels above 10 microg/dL (P=0.006). The median tibia lead level was 17 micrograms of lead per gram of bone mineral (microg/g) and 13 microg/g among ESRD cases and their control counterparts, respectively (P=0.134). Four ESRD cases (7%), but no controls, had a tibia lead level above 40 microg/g (P=0.115) while a similar proportion of cases and controls had tibia lead between 20 and 39 microg/g (33% and 32%, respectively; P=0.726). After adjustment for potential confounders, the odds ratios of ESRD associated with a tibia lead > or = 20 microg/g and each four-fold higher tibia lead (e.g., 5-20 microg/g) were 1.55 (95% CI: 0.55, 4.41) and 1.88 (95% CI: 0.53, 6.68), respectively. These findings support the need for prospective cohort studies of body lead burden and renal disease progression. IS - 3 JF - Environmental research SN - 0013-9351 EP - 401 TI - Association of tibia lead and blood lead with end-stage renal disease: a pilot study of African-Americans. VL - 104 SP - 396 KW - african_american KW - kidney KW - lead KW - lead_bone KW - renal KW - tibia AU - Muntner, P AU - Menke, A AU - Batuman, V AU - Rabito, FA AU - He, J AU - Todd, AC PY - 2007/07// UR - http://dx.doi.org/10.1016/j.envres.2007.04.001 ER -