Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. Export

@article{Tamas:NatNeuro:2000, abstract = {Networks of GABAergic interneurons are implicated in synchronizing cortical activity at gamma frequencies (30-70 Hz). Here we demonstrate that the combined electrical and GABAergic synaptic coupling of basket cells instantaneously entrained gamma-frequency postsynaptic firing in layers 2/3 of rat somatosensory cortex. This entrainment was mediated by rapid curtailment of gap junctional coupling potentials by GABAA receptor-mediated IPSPs. Electron microscopy revealed spatial proximity of gap junctions and GABAergic synapses on somata and dendrites. Electrical coupling alone entrained postsynaptic firing with a phase lag, whereas unitary GABAergic connections were ineffective in gamma-frequency phasing. These observations demonstrate precise spatiotemporal mechanisms underlying action potential timing in oscillating interneuronal networks.}, address = {Department of Comparative Physiology, University of Szeged, K\"{o}z\'{e}pfasor 52, Szeged H-6726, Hungary. gtamas@sol.cc.u-szeged.hu}, author = {Tam\'{a}s, G. and Buhl, E. H. and L\"{o}rincz, A. and Somogyi, P.}, citeulike-article-id = {134402}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/73936}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10725926}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10725926}, doi = {10.1038/73936}, issn = {1097-6256}, journal = {Nature neuroscience}, keywords = {basket\_cells, gamma}, month = {April}, number = {4}, pages = {366--371}, posted-at = {2009-10-31 16:57:23}, priority = {2}, title = {Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons.}, url = {http://dx.doi.org/10.1038/73936}, volume = {3}, year = {2000} }

TY - JOUR ID - Tamas:NatNeuro:2000 L3 - citeulike-article-id:134402 N2 - Networks of GABAergic interneurons are implicated in synchronizing cortical activity at gamma frequencies (30-70 Hz). Here we demonstrate that the combined electrical and GABAergic synaptic coupling of basket cells instantaneously entrained gamma-frequency postsynaptic firing in layers 2/3 of rat somatosensory cortex. This entrainment was mediated by rapid curtailment of gap junctional coupling potentials by GABAA receptor-mediated IPSPs. Electron microscopy revealed spatial proximity of gap junctions and GABAergic synapses on somata and dendrites. Electrical coupling alone entrained postsynaptic firing with a phase lag, whereas unitary GABAergic connections were ineffective in gamma-frequency phasing. These observations demonstrate precise spatiotemporal mechanisms underlying action potential timing in oscillating interneuronal networks. IS - 4 JF - Nature neuroscience SN - 1097-6256 AD - Department of Comparative Physiology, University of Szeged, Középfasor 52, Szeged H-6726, Hungary. gtamas@sol.cc.u-szeged.hu EP - 371 TI - Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons. VL - 3 SP - 366 KW - basket_cells KW - gamma AU - Tamás, G AU - Buhl, EH AU - Lörincz, A AU - Somogyi, P PY - 2000/04// UR - http://dx.doi.org/10.1038/73936 ER -