Coupling between Neuronal Firing Rate, Gamma LFP, and BOLD fMRI Is Related to Interneuronal Correlations Export

@article{Nir:CurrOpin:1007, abstract = {SummaryBackground To what extent is activity of individual neurons coupled to the local field potential (LFP) and to blood-oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI)? This issue is of high significance for understanding brain function and for relating animal studies to fMRI, yet it is still under debate.Results Here we report data from simultaneous recordings of isolated unit activity and LFP by using multiple electrodes in the human auditory cortex. We found a wide range of coupling levels between the activity of individual neurons and gamma LFP. However, this large variability could be predominantly explained (r = 0.66) by the degree of firing-rate correlations between neighboring neurons. Importantly, this phenomenon occurred during both sensory stimulation and spontaneous activity. Concerning the coupling of neuronal activity to BOLD fMRI, we found that gamma LFP was well coupled to BOLD measured across different individuals (r = 0.62). By contrast, the coupling of single units to BOLD was highly variable and, again, tightly related to interneuronal-firing-rate correlations (r = 0.70).Conclusions Our results offer a resolution to a central controversy regarding the coupling between neurons, LFP, and BOLD signals by demonstrating, for the first time, that the coupling of single units to the other measures is variable yet it is tightly related to the degree of interneuronal correlations in the human auditory cortex.}, author = {Nir, Yuval and Fisch, Lior and Mukamel, Roy and Gelbard-Sagiv, Hagar and Arieli, Amos and Fried, Itzhak and Malach, Rafael}, citeulike-article-id = {1540894}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cub.2007.06.066}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17686438}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17686438}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6VRT-4PC3JHV-S/2/dadd2abe3b1acb08bf835ee10dedc52d}, day = {7}, doi = {10.1016/j.cub.2007.06.066}, journal = {Current Biology}, keywords = {bold, firingrate, gamma, human}, month = {August}, number = {15}, pages = {1275--1285}, posted-at = {2008-10-13 15:34:01}, priority = {2}, title = {Coupling between Neuronal Firing Rate, Gamma LFP, and BOLD fMRI Is Related to Interneuronal Correlations}, url = {http://dx.doi.org/10.1016/j.cub.2007.06.066}, volume = {17}, year = {2007} }

TY - JOUR ID - Nir:CurrOpin:1007 L3 - citeulike-article-id:1540894 N2 - SummaryBackground To what extent is activity of individual neurons coupled to the local field potential (LFP) and to blood-oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI)? This issue is of high significance for understanding brain function and for relating animal studies to fMRI, yet it is still under debate.Results Here we report data from simultaneous recordings of isolated unit activity and LFP by using multiple electrodes in the human auditory cortex. We found a wide range of coupling levels between the activity of individual neurons and gamma LFP. However, this large variability could be predominantly explained (r = 0.66) by the degree of firing-rate correlations between neighboring neurons. Importantly, this phenomenon occurred during both sensory stimulation and spontaneous activity. Concerning the coupling of neuronal activity to BOLD fMRI, we found that gamma LFP was well coupled to BOLD measured across different individuals (r = 0.62). By contrast, the coupling of single units to BOLD was highly variable and, again, tightly related to interneuronal-firing-rate correlations (r = 0.70).Conclusions Our results offer a resolution to a central controversy regarding the coupling between neurons, LFP, and BOLD signals by demonstrating, for the first time, that the coupling of single units to the other measures is variable yet it is tightly related to the degree of interneuronal correlations in the human auditory cortex. IS - 15 JF - Current Biology EP - 1285 TI - Coupling between Neuronal Firing Rate, Gamma LFP, and BOLD fMRI Is Related to Interneuronal Correlations VL - 17 SP - 1275 KW - bold KW - firingrate KW - gamma KW - human AU - Nir, Yuval AU - Fisch, Lior AU - Mukamel, Roy AU - Gelbard-Sagiv, Hagar AU - Arieli, Amos AU - Fried, Itzhak AU - Malach, Rafael PY - 2007/08/07/ UR - http://dx.doi.org/10.1016/j.cub.2007.06.066 ER -