Are spatial memories strengthened in the human hippocampus during slow wave sleep? Export

@article{Peigneux:Neuron:2004, abstract = {In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of spatial memories. Here, using regional cerebral blood flow measurements, we show that, in humans, hippocampal areas that are activated during route learning in a virtual town are likewise activated during subsequent slow wave sleep. Most importantly, we found that the amount of hippocampal activity expressed during slow wave sleep positively correlates with the improvement of performance in route retrieval on the next day. These findings suggest that learning-dependent modulation in hippocampal activity during human sleep reflects the offline processing of recent episodic and spatial memory traces, which eventually leads to the plastic changes underlying the subsequent improvement in performance.}, address = {Cyclotron Research Center, University of Li\`{e}ge, B-4000 Li\`{e}ge, Belgium. philippe.peigneux@ulg.ac.be}, author = {Peigneux, P. and Laureys, S. and Fuchs, S. and Collette, F. and Perrin, F. and Reggers, J. and Phillips, C. and Degueldre, C. and Del Fiore, G. and Aerts, J. and Luxen, A. and Maquet, P.}, citeulike-article-id = {2304607}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2004.10.007}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896-6273(04)00645-2}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15504332}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15504332}, day = {28}, doi = {10.1016/j.neuron.2004.10.007}, issn = {0896-6273}, journal = {Neuron}, keywords = {humans, sleep, sws}, month = {October}, number = {3}, pages = {535--545}, posted-at = {2009-03-16 15:25:23}, priority = {2}, title = {Are spatial memories strengthened in the human hippocampus during slow wave sleep?}, url = {http://dx.doi.org/10.1016/j.neuron.2004.10.007}, volume = {44}, year = {2004} }

TY - JOUR ID - Peigneux:Neuron:2004 L3 - citeulike-article-id:2304607 N2 - In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of spatial memories. Here, using regional cerebral blood flow measurements, we show that, in humans, hippocampal areas that are activated during route learning in a virtual town are likewise activated during subsequent slow wave sleep. Most importantly, we found that the amount of hippocampal activity expressed during slow wave sleep positively correlates with the improvement of performance in route retrieval on the next day. These findings suggest that learning-dependent modulation in hippocampal activity during human sleep reflects the offline processing of recent episodic and spatial memory traces, which eventually leads to the plastic changes underlying the subsequent improvement in performance. IS - 3 JF - Neuron SN - 0896-6273 AD - Cyclotron Research Center, University of Liège, B-4000 Liège, Belgium. philippe.peigneux@ulg.ac.be EP - 545 TI - Are spatial memories strengthened in the human hippocampus during slow wave sleep? VL - 44 SP - 535 KW - humans KW - sleep KW - sws AU - Peigneux, P AU - Laureys, S AU - Fuchs, S AU - Collette, F AU - Perrin, F AU - Reggers, J AU - Phillips, C AU - Degueldre, C AU - Del Fiore, G AU - Aerts, J AU - Luxen, A AU - Maquet, P PY - 2004/10/28/ UR - http://dx.doi.org/10.1016/j.neuron.2004.10.007 ER -