Redistribution of synaptic efficacy between neocortical pyramidal neurons. Export

@article{Markram:Nature:1996, abstract = {Experience-dependent potentiation and depression of synaptic strength has been proposed to subserve learning and memory by changing the gain of signals conveyed between neurons. Here we examine synaptic plasticity between individual neocortical layer-5 pyramidal neurons. We show that an increase in the synaptic response, induced by pairing action-potential activity in pre- and postsynaptic neurons, was only observed when synaptic input occurred at low frequencies. This frequency-dependent increase in synaptic responses arises because of a redistribution of the available synaptic efficacy and not because of an increase in the efficacy. Redistribution of synaptic efficacy could represent a mechanism to change the content, rather than the gain, of signals conveyed between neurons.}, address = {Department of Neurobiology, The Weizmann Institute for Science, Rehovot, Israel.}, author = {Markram, H. and Tsodyks, M.}, citeulike-article-id = {2689507}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/382807a0}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/382807a0}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/8752273}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=8752273}, day = {29}, doi = {10.1038/382807a0}, issn = {0028-0836}, journal = {Nature}, keywords = {dynamicalsynapse}, month = {August}, number = {6594}, pages = {807--810}, posted-at = {2009-02-26 11:51:38}, priority = {2}, title = {Redistribution of synaptic efficacy between neocortical pyramidal neurons.}, url = {http://dx.doi.org/10.1038/382807a0}, volume = {382}, year = {1996} }

TY - JOUR ID - Markram:Nature:1996 L3 - citeulike-article-id:2689507 N2 - Experience-dependent potentiation and depression of synaptic strength has been proposed to subserve learning and memory by changing the gain of signals conveyed between neurons. Here we examine synaptic plasticity between individual neocortical layer-5 pyramidal neurons. We show that an increase in the synaptic response, induced by pairing action-potential activity in pre- and postsynaptic neurons, was only observed when synaptic input occurred at low frequencies. This frequency-dependent increase in synaptic responses arises because of a redistribution of the available synaptic efficacy and not because of an increase in the efficacy. Redistribution of synaptic efficacy could represent a mechanism to change the content, rather than the gain, of signals conveyed between neurons. IS - 6594 JF - Nature SN - 0028-0836 AD - Department of Neurobiology, The Weizmann Institute for Science, Rehovot, Israel. EP - 810 TI - Redistribution of synaptic efficacy between neocortical pyramidal neurons. VL - 382 SP - 807 KW - dynamicalsynapse AU - Markram, H AU - Tsodyks, M PY - 1996/08/29/ UR - http://dx.doi.org/10.1038/382807a0 ER -