Two distinct activity patterns of fast-spiking interneurons during neocortical UP states. Export

@article{Puig:PNAS:2008, abstract = {During sleep, neocortical neuronal networks oscillate slowly (<1 Hz) between periods of activity (UP states) and silence (DOWN states). UP states favor the interaction between thalamic-generated spindles (7-14 Hz) and cortically generated gamma (30-80 Hz) waves. We studied how these three nested oscillations modulate fast-spiking interneuron (FSi) activity in vivo in VGAT-Venus transgenic rats. Our data describe a population of FSi that discharge "early" within UP states and another population that discharge "late." Early FSi tended to be silent during epochs of desynchronization, whereas late FSi were active. We hypothesize that late FSi may be responsible for generating the gamma oscillations associated with cognitive processing during wakefulness. Remarkably, FSi populations were differently modulated by spindle and gamma rhythms. Early FSi were robustly coupled to spindles and always discharged earlier than late FSi within spindle and gamma cycles. The preferred firing phase during spindle and gamma waves was strongly correlated in each cell, suggesting a cross-frequency coupling between oscillations. Our results suggest a precise spatiotemporal pattern of FSi activity during UP states, whereby information rapidly flows between early and late cells, initially promoted by spindles and efficiently extended by local gamma oscillations.}, address = {Division of Cerebral Circuitry, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8787, Japan.}, author = {Puig, Maria Victoria V. and Ushimaru, Mika and Kawaguchi, Yasuo}, citeulike-article-id = {2908047}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0712219105}, citeulike-linkout-1 = {http://www.pnas.org/cgi/content/abstract/105/24/8428}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18550841}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18550841}, day = {17}, doi = {10.1073/pnas.0712219105}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {interneurons, spindle, uds}, month = {June}, number = {24}, pages = {8428--8433}, posted-at = {2009-11-02 10:09:18}, priority = {2}, title = {Two distinct activity patterns of fast-spiking interneurons during neocortical UP states.}, url = {http://dx.doi.org/10.1073/pnas.0712219105}, volume = {105}, year = {2008} }

TY - JOUR ID - Puig:PNAS:2008 L3 - citeulike-article-id:2908047 N2 - During sleep, neocortical neuronal networks oscillate slowly (<1 Hz) between periods of activity (UP states) and silence (DOWN states). UP states favor the interaction between thalamic-generated spindles (7-14 Hz) and cortically generated gamma (30-80 Hz) waves. We studied how these three nested oscillations modulate fast-spiking interneuron (FSi) activity in vivo in VGAT-Venus transgenic rats. Our data describe a population of FSi that discharge "early" within UP states and another population that discharge "late." Early FSi tended to be silent during epochs of desynchronization, whereas late FSi were active. We hypothesize that late FSi may be responsible for generating the gamma oscillations associated with cognitive processing during wakefulness. Remarkably, FSi populations were differently modulated by spindle and gamma rhythms. Early FSi were robustly coupled to spindles and always discharged earlier than late FSi within spindle and gamma cycles. The preferred firing phase during spindle and gamma waves was strongly correlated in each cell, suggesting a cross-frequency coupling between oscillations. Our results suggest a precise spatiotemporal pattern of FSi activity during UP states, whereby information rapidly flows between early and late cells, initially promoted by spindles and efficiently extended by local gamma oscillations. IS - 24 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 AD - Division of Cerebral Circuitry, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8787, Japan. EP - 8433 TI - Two distinct activity patterns of fast-spiking interneurons during neocortical UP states. VL - 105 SP - 8428 KW - interneurons KW - spindle KW - uds AU - Puig, Maria Victoria AU - Ushimaru, Mika AU - Kawaguchi, Yasuo PY - 2008/06/17/ UR - http://dx.doi.org/10.1073/pnas.0712219105 ER -