Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation. Export

@article{Gais:PNAS:2004, abstract = {The neurotransmitter acetylcholine is considered essential for proper functioning of the hippocampus-dependent declarative memory system, and it represents a major neuropharmacological target for the treatment of memory deficits, such as those in Alzheimer's disease. During slow-wave sleep (SWS), however, declarative memory consolidation is particularly strong, while acetylcholine levels in the hippocampus drop to a minimum. Observations in rats led to the hypothesis that the low cholinergic tone during SWS is necessary for the replay of new memories in the hippocampus and their long-term storage in neocortical networks. However, this low tone should not affect nondeclarative memory systems. In this study, increasing central nervous cholinergic activation during SWS-rich sleep by posttrial infusion of 0.75 mg of the cholinesterase inhibitor physostigmine completely blocked SWS-related consolidation of declarative memories for word pairs in human subjects. The treatment did not interfere with consolidation of a nondeclarative mirror tracing task. Also, physostigmine did not alter memory consolidation during waking, when the endogenous central nervous cholinergic tone is maximal. These findings are in line with predictions that a low cholinergic tone during SWS is essential for declarative memory consolidation.}, author = {Gais, S. and Born, J.}, citeulike-article-id = {4183526}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0305404101}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14766981}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14766981}, day = {17}, doi = {10.1073/pnas.0305404101}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {acetylcholine, humans, sws}, month = {February}, number = {7}, pages = {2140--2144}, posted-at = {2009-03-16 15:46:33}, priority = {2}, title = {Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation.}, url = {http://dx.doi.org/10.1073/pnas.0305404101}, volume = {101}, year = {2004} }

TY - JOUR ID - Gais:PNAS:2004 L3 - citeulike-article-id:4183526 N2 - The neurotransmitter acetylcholine is considered essential for proper functioning of the hippocampus-dependent declarative memory system, and it represents a major neuropharmacological target for the treatment of memory deficits, such as those in Alzheimer's disease. During slow-wave sleep (SWS), however, declarative memory consolidation is particularly strong, while acetylcholine levels in the hippocampus drop to a minimum. Observations in rats led to the hypothesis that the low cholinergic tone during SWS is necessary for the replay of new memories in the hippocampus and their long-term storage in neocortical networks. However, this low tone should not affect nondeclarative memory systems. In this study, increasing central nervous cholinergic activation during SWS-rich sleep by posttrial infusion of 0.75 mg of the cholinesterase inhibitor physostigmine completely blocked SWS-related consolidation of declarative memories for word pairs in human subjects. The treatment did not interfere with consolidation of a nondeclarative mirror tracing task. Also, physostigmine did not alter memory consolidation during waking, when the endogenous central nervous cholinergic tone is maximal. These findings are in line with predictions that a low cholinergic tone during SWS is essential for declarative memory consolidation. IS - 7 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 2144 TI - Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation. VL - 101 SP - 2140 KW - acetylcholine KW - humans KW - sws AU - Gais, S AU - Born, J PY - 2004/02/17/ UR - http://dx.doi.org/10.1073/pnas.0305404101 ER -