The hydrophobic effect. 1. A consequence of the mobile order in H-bonded liquids Export

@article{citeulike:1983213, abstract = {The hydrophobic effect has an entropic nature that cannot be explained by classical multicomponent treatments that do not explicitly take into account both the mobility and the nonergodicity of the H-bonds in amphiphilic liquids. The nonergodic thermodynamics of mobile order in H-bonded liquids based on time fractions rather than on concentrations provides a novel qualitative and quantitative explanation for the molecular origin of the hydrophobic effect. Chiefly, this effect corresponds to the loss of the mobile order entropy of associated molecules by dilution with foreign substances. Not being a unique property of water, the propensity of an amphiphilic solvent to induce a solvophobic effect increases primarily as its structuration factor increases, and secondarity as the solute/solvent molar volume ratio increases. On this basis, it can be expected that in the absence of strong solute-solvent specific interactions, the solubility of non-electrolytes will generally decrease in the following order: butanol \> propanol \> ethanol \> methanol \> propylene glycol \> ethylene glycol \> formamide \> water.}, address = {Institut d'Analyse Pharmaceutique, Section de Pharmacie, Universit\'{e} de Lausanne, B E P, CH-1015 Lausanne, Switzerland.}, author = {Ruelle, Paul and Kesselring, Ulrich W.}, citeulike-article-id = {1983213}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/js970205e}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/js970205e}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/9687344}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=9687344}, citeulike-linkout-4 = {http://www3.interscience.wiley.com/cgi-bin/abstract/72505774/ABSTRACT}, doi = {10.1021/js970205e}, journal = {Journal of Pharmaceutical Sciences}, keywords = {basics, hydrophobic}, number = {8}, pages = {987--997}, posted-at = {2008-01-03 21:16:18}, priority = {2}, title = {The hydrophobic effect. 1. A consequence of the mobile order in H-bonded liquids}, url = {http://dx.doi.org/10.1021/js970205e}, volume = {87}, year = {1998} }

TY - JOUR ID - citeulike:1983213 L3 - citeulike-article-id:1983213 N2 - The hydrophobic effect has an entropic nature that cannot be explained by classical multicomponent treatments that do not explicitly take into account both the mobility and the nonergodicity of the H-bonds in amphiphilic liquids. The nonergodic thermodynamics of mobile order in H-bonded liquids based on time fractions rather than on concentrations provides a novel qualitative and quantitative explanation for the molecular origin of the hydrophobic effect. Chiefly, this effect corresponds to the loss of the mobile order entropy of associated molecules by dilution with foreign substances. Not being a unique property of water, the propensity of an amphiphilic solvent to induce a solvophobic effect increases primarily as its structuration factor increases, and secondarity as the solute/solvent molar volume ratio increases. On this basis, it can be expected that in the absence of strong solute-solvent specific interactions, the solubility of non-electrolytes will generally decrease in the following order: butanol > propanol > ethanol > methanol > propylene glycol > ethylene glycol > formamide > water. IS - 8 JF - Journal of Pharmaceutical Sciences AD - Institut d'Analyse Pharmaceutique, Section de Pharmacie, Université de Lausanne, B E P, CH-1015 Lausanne, Switzerland. EP - 997 TI - The hydrophobic effect. 1. A consequence of the mobile order in H-bonded liquids VL - 87 SP - 987 KW - basics KW - hydrophobic AU - Ruelle, Paul AU - Kesselring, Ulrich PY - 1998/// UR - http://dx.doi.org/10.1021/js970205e ER -