Increased Frequency of Learning Disability in Patients With Primary Progressive Aphasia and Their First-Degree Relatives Export

@article{EmilyRogalski02012008, abstract = {Background Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA). Objective To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members. Design, Setting, and Patients Self-report endorsement of an individual and family history of an LD in a sample of 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic Alzheimer disease, and the behavioral variant of frontotemporal dementia) and 1 elderly control group. A retrospective medical record review in the PPA probands was used to obtain additional information. Main Outcome Measure Prevalence of LDs among probands and their first-degree relatives. Results The patients with PPA and their first-degree family members had a significantly higher frequency of LD compared with the other dementia groups and the controls. Some of the families of patients with PPA displayed unusual concentrations of LD, especially dyslexia. Conclusion These results suggest that LD may constitute a risk factor for PPA, providing additional clues concerning the determinants for the selective vulnerability of the language network in this syndrome.}, author = {Rogalski, Emily and Johnson, Nancy and Weintraub, Sandra and Mesulam, Marsel}, citeulike-article-id = {2363950}, citeulike-linkout-0 = {http://archneur.ama-assn.org/cgi/content/abstract/65/2/244}, doi = {10.1001/archneurol.2007.34}, eprint = {http://archneur.ama-assn.org/cgi/reprint/65/2/244.pdf}, journal = {Arch Neurol}, keywords = {aphasia, ftd, primary, progressive}, number = {2}, pages = {244--248}, posted-at = {2008-02-11 21:58:52}, priority = {4}, title = {{Increased Frequency of Learning Disability in Patients With Primary Progressive Aphasia and Their First-Degree Relatives}}, url = {10.1001/archneurol.2007.34}, volume = {65}, year = {2008} }

TY - JOUR ID - EmilyRogalski02012008 L3 - citeulike-article-id:2363950 N2 - Background Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA). Objective To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members. Design, Setting, and Patients Self-report endorsement of an individual and family history of an LD in a sample of 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic Alzheimer disease, and the behavioral variant of frontotemporal dementia) and 1 elderly control group. A retrospective medical record review in the PPA probands was used to obtain additional information. Main Outcome Measure Prevalence of LDs among probands and their first-degree relatives. Results The patients with PPA and their first-degree family members had a significantly higher frequency of LD compared with the other dementia groups and the controls. Some of the families of patients with PPA displayed unusual concentrations of LD, especially dyslexia. Conclusion These results suggest that LD may constitute a risk factor for PPA, providing additional clues concerning the determinants for the selective vulnerability of the language network in this syndrome. IS - 2 JF - Arch Neurol EP - 248 TI - {Increased Frequency of Learning Disability in Patients With Primary Progressive Aphasia and Their First-Degree Relatives} VL - 65 SP - 244 KW - aphasia KW - ftd KW - primary KW - progressive AU - Rogalski, Emily AU - Johnson, Nancy AU - Weintraub, Sandra AU - Mesulam, Marsel PY - 2008/// UR - http://archneur.ama-assn.org/cgi/content/abstract/65/2/244 ER -