Repetitive immunization enhances the susceptibility of mice to peripherally administered prions. Export

@article{citeulike:5869939, abstract = {The susceptibility of humans and animals to prion infections is determined by the virulence of the infectious agent, by genetic modifiers, and by hitherto unknown host and environmental risk factors. While little is known about the latter two, the activation state of the immune system was surmised to influence prion susceptibility. Here we administered prions to mice that were repeatedly immunized by two initial injections of CpG oligodeoxynucleotides followed by repeated injections of bovine serum albumin/alum. Immunization greatly reduced the required dosage of peripherally administered prion inoculum necessary to induce scrapie in 50\% of mice. No difference in susceptibility was observed following intracerebral prion challenge. Due to its profound impact onto scrapie susceptibility, the host immune status may determine disease penetrance after low-dose prion exposure, including those that may give rise to iatrogenic and variant Creutzfeldt-Jakob disease.}, author = {Bremer, Juliane and Heikenwalder, Mathias and Haybaeck, Johannes and Tiberi, Cinzia and Krautler, Nike Julia J. and Kurrer, Michael O. and Aguzzi, Adriano}, citeulike-article-id = {5869939}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0007160}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19779609}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19779609}, doi = {10.1371/journal.pone.0007160}, issn = {1932-6203}, journal = {PloS one}, keywords = {cjd, prion, risk}, number = {9}, posted-at = {2009-10-01 21:16:03}, priority = {4}, title = {Repetitive immunization enhances the susceptibility of mice to peripherally administered prions.}, url = {http://dx.doi.org/10.1371/journal.pone.0007160}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:5869939 L3 - citeulike-article-id:5869939 N2 - The susceptibility of humans and animals to prion infections is determined by the virulence of the infectious agent, by genetic modifiers, and by hitherto unknown host and environmental risk factors. While little is known about the latter two, the activation state of the immune system was surmised to influence prion susceptibility. Here we administered prions to mice that were repeatedly immunized by two initial injections of CpG oligodeoxynucleotides followed by repeated injections of bovine serum albumin/alum. Immunization greatly reduced the required dosage of peripherally administered prion inoculum necessary to induce scrapie in 50% of mice. No difference in susceptibility was observed following intracerebral prion challenge. Due to its profound impact onto scrapie susceptibility, the host immune status may determine disease penetrance after low-dose prion exposure, including those that may give rise to iatrogenic and variant Creutzfeldt-Jakob disease. IS - 9 JF - PloS one SN - 1932-6203 TI - Repetitive immunization enhances the susceptibility of mice to peripherally administered prions. VL - 4 KW - cjd KW - prion KW - risk AU - Bremer, Juliane AU - Heikenwalder, Mathias AU - Haybaeck, Johannes AU - Tiberi, Cinzia AU - Krautler, Nike Julia AU - Kurrer, Michael AU - Aguzzi, Adriano PY - 2009/// UR - http://dx.doi.org/10.1371/journal.pone.0007160 ER -