PrPTSE in muscle-associated lymphatic tissue during the preclinical stage of mice infected orally with bovine spongiform encephalopathy Export

@article{citeulike:6032496, abstract = {The involvement of muscles in the pathogenesis of transmissible spongiform encephalopathies (TSEs) is irregular and unpredictable. We show that the TSE-specific protein (PrPTSE) is present in muscles of mice fed with a mouse-adapted strain of bovine spongiform encephalopathy as early as 100 days post-infection, corresponding to about one-third of the incubation period. The proportion of mice with PrPTSE-positive muscles and the number of muscles involved increased as infection progressed, but never attained more than a limited distribution, even at the clinical stage of disease. The appearance of PrPTSE in muscles during the preclinical stage of disease was probably due to the haematogenous/lymphatic spread of infectivity from the gastrointestinal tract to lymphatic tissues associated with muscles, whereas in symptomatic animals, the presence of PrPTSE in the nervous system, in neuromuscular junctions and in muscle fibres suggests a centrifugal spread from the central nervous system, as already observed in other TSE models. 10.1099/vir.0.010801-0}, author = {Cardone, Franco and Thomzig, Achim and Schulz-Schaeffer, Walter and Valanzano, Angelina and Sbriccoli, Marco and Abdel-Haq, Hanin and Graziano, Silvia and Pritzkow, Sandra and Puopolo, Maria and Brown, Paul and Beekes, Michael and Pocchiari, Maurizio}, citeulike-article-id = {6032496}, citeulike-linkout-0 = {http://dx.doi.org/10.1099/vir.0.010801-0}, citeulike-linkout-1 = {http://vir.sgmjournals.org/content/90/10/2563.abstract}, citeulike-linkout-2 = {http://vir.sgmjournals.org/content/90/10/2563.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19535501}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19535501}, day = {1}, doi = {10.1099/vir.0.010801-0}, journal = {J Gen Virol}, keywords = {bse, lymphatic, muscle, preclinical, prion, tse}, month = {October}, number = {10}, pages = {2563--2568}, posted-at = {2009-10-29 15:49:53}, priority = {4}, title = {PrPTSE in muscle-associated lymphatic tissue during the preclinical stage of mice infected orally with bovine spongiform encephalopathy}, url = {http://dx.doi.org/10.1099/vir.0.010801-0}, volume = {90}, year = {2009} }

TY - JOUR ID - citeulike:6032496 L3 - citeulike-article-id:6032496 N2 - The involvement of muscles in the pathogenesis of transmissible spongiform encephalopathies (TSEs) is irregular and unpredictable. We show that the TSE-specific protein (PrPTSE) is present in muscles of mice fed with a mouse-adapted strain of bovine spongiform encephalopathy as early as 100 days post-infection, corresponding to about one-third of the incubation period. The proportion of mice with PrPTSE-positive muscles and the number of muscles involved increased as infection progressed, but never attained more than a limited distribution, even at the clinical stage of disease. The appearance of PrPTSE in muscles during the preclinical stage of disease was probably due to the haematogenous/lymphatic spread of infectivity from the gastrointestinal tract to lymphatic tissues associated with muscles, whereas in symptomatic animals, the presence of PrPTSE in the nervous system, in neuromuscular junctions and in muscle fibres suggests a centrifugal spread from the central nervous system, as already observed in other TSE models. 10.1099/vir.0.010801-0 IS - 10 JF - J Gen Virol EP - 2568 TI - PrPTSE in muscle-associated lymphatic tissue during the preclinical stage of mice infected orally with bovine spongiform encephalopathy VL - 90 SP - 2563 KW - bse KW - lymphatic KW - muscle KW - preclinical KW - prion KW - tse AU - Cardone, Franco AU - Thomzig, Achim AU - Schulz-Schaeffer, Walter AU - Valanzano, Angelina AU - Sbriccoli, Marco AU - Abdel-Haq, Hanin AU - Graziano, Silvia AU - Pritzkow, Sandra AU - Puopolo, Maria AU - Brown, Paul AU - Beekes, Michael AU - Pocchiari, Maurizio PY - 2009/10/01/ UR - http://dx.doi.org/10.1099/vir.0.010801-0 ER -