Mechanisms regulating imprinted genes in clusters Export

@article{citeulike:2587673, abstract = {Clustered imprinted genes are regulated by differentially methylated imprinting control regions (ICRs) that affect gene activity and repression in cis over a large region. Although a primary imprint signal for each of these clusters is DNA methylation, different mechanisms are used to establish and maintain these marks. The majority of ICRs are methylated in the maternal germline and are usually promoters for antisense transcripts whose elongation is associated with imprinting control in the domain. In contrast, ICRs methylated in the paternal germline do not appear to act as promoters and are located between genes. At least one, at the Igf2/H19 locus, is known to function as an insulator. Analysis of ICRs suggests that maternal and paternal methylation imprints function in distinct ways.}, address = {Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.}, author = {Edwards, C. and Fergusonsmith, A.}, citeulike-article-id = {2587673}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ceb.2007.04.013}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0955067407000658}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17467259}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17467259}, doi = {10.1016/j.ceb.2007.04.013}, issn = {09550674}, journal = {Current Opinion in Cell Biology}, keywords = {clusters, dmr, dna\_methylation, icr, imprinting, methylation}, month = {June}, number = {3}, pages = {281--289}, posted-at = {2009-11-05 14:46:25}, priority = {2}, title = {Mechanisms regulating imprinted genes in clusters}, url = {http://dx.doi.org/10.1016/j.ceb.2007.04.013}, volume = {19}, year = {2007} }

TY - JOUR ID - citeulike:2587673 L3 - citeulike-article-id:2587673 N2 - Clustered imprinted genes are regulated by differentially methylated imprinting control regions (ICRs) that affect gene activity and repression in cis over a large region. Although a primary imprint signal for each of these clusters is DNA methylation, different mechanisms are used to establish and maintain these marks. The majority of ICRs are methylated in the maternal germline and are usually promoters for antisense transcripts whose elongation is associated with imprinting control in the domain. In contrast, ICRs methylated in the paternal germline do not appear to act as promoters and are located between genes. At least one, at the Igf2/H19 locus, is known to function as an insulator. Analysis of ICRs suggests that maternal and paternal methylation imprints function in distinct ways. IS - 3 JF - Current Opinion in Cell Biology SN - 09550674 AD - Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK. EP - 289 TI - Mechanisms regulating imprinted genes in clusters VL - 19 SP - 281 KW - clusters KW - dmr KW - dna_methylation KW - icr KW - imprinting KW - methylation AU - Edwards, C AU - Fergusonsmith, A PY - 2007/06// UR - http://dx.doi.org/10.1016/j.ceb.2007.04.013 ER -