Rethinking how DNA methylation patterns are maintained Export

@article{citeulike:5904173, abstract = {DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells. A long-established model for the maintenance of these patterns explains some, but not all, of the data that are now available. We propose a new model that suggests that the maintenance of DNA methylation relies not only on the recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that contain methylated DNA.}, author = {Jones, Peter A. and Liang, Gangning}, citeulike-article-id = {5904173}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2651}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2651}, day = {30}, doi = {10.1038/nrg2651}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {cpg, dna-methylation, dna\_methyltransferases, dnmt3l, patterning}, month = {September}, number = {11}, pages = {805--811}, posted-at = {2009-11-06 11:07:03}, priority = {2}, publisher = {Nature Publishing Group}, title = {Rethinking how DNA methylation patterns are maintained}, url = {http://dx.doi.org/10.1038/nrg2651}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5904173 L3 - citeulike-article-id:5904173 N2 - DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells. A long-established model for the maintenance of these patterns explains some, but not all, of the data that are now available. We propose a new model that suggests that the maintenance of DNA methylation relies not only on the recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that contain methylated DNA. IS - 11 JF - Nature Reviews Genetics SN - 1471-0056 EP - 811 TI - Rethinking how DNA methylation patterns are maintained PB - Nature Publishing Group VL - 10 SP - 805 KW - cpg KW - dna-methylation KW - dna_methyltransferases KW - dnmt3l KW - patterning AU - Jones, Peter AU - Liang, Gangning PY - 2009/09/30/ UR - http://dx.doi.org/10.1038/nrg2651 ER -