Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior Export

@article{citeulike:1168016, abstract = {A key process in organ homeostasis is the mobilization of stem cells out of their niches. We show through analysis of mouse models that telomere length, as well as the catalytic component of telomerase, Tert, are critical determinants in the mobilization of epidermal stem cells. Telomere shortening inhibited mobilization of stem cells out of their niche, impaired hair growth, and resulted in suppression of stem cell proliferative capacity in vitro. In contrast, Tert overexpression in the absence of changes in telomere length promoted stem cell mobilization, hair growth, and stem cell proliferation in vitro. The effects of telomeres and telomerase on stem cell biology anticipate their role in cancer and aging. 10.1126/science.1115025}, author = {Flores, Ignacio and Cayuela, Maria L. and Blasco, Maria A.}, citeulike-article-id = {1168016}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1115025}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/309/5738/1253}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16037417}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16037417}, day = {19}, doi = {10.1126/science.1115025}, journal = {Science}, keywords = {aging, cancer, stemcells}, month = {August}, number = {5738}, pages = {1253--1256}, posted-at = {2007-03-16 22:18:02}, priority = {2}, title = {Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior}, url = {http://dx.doi.org/10.1126/science.1115025}, volume = {309}, year = {2005} }

TY - JOUR ID - citeulike:1168016 L3 - citeulike-article-id:1168016 N2 - A key process in organ homeostasis is the mobilization of stem cells out of their niches. We show through analysis of mouse models that telomere length, as well as the catalytic component of telomerase, Tert, are critical determinants in the mobilization of epidermal stem cells. Telomere shortening inhibited mobilization of stem cells out of their niche, impaired hair growth, and resulted in suppression of stem cell proliferative capacity in vitro. In contrast, Tert overexpression in the absence of changes in telomere length promoted stem cell mobilization, hair growth, and stem cell proliferation in vitro. The effects of telomeres and telomerase on stem cell biology anticipate their role in cancer and aging. 10.1126/science.1115025 IS - 5738 JF - Science EP - 1256 TI - Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior VL - 309 SP - 1253 KW - aging KW - cancer KW - stemcells AU - Flores, Ignacio AU - Cayuela, Maria AU - Blasco, Maria PY - 2005/08/19/ UR - http://dx.doi.org/10.1126/science.1115025 ER -