Chk1 and Chk2 kinases in checkpoint control and cancer. Export

@article{citeulike:1177547, abstract = {Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer cells. This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways. Here, we discuss the emerging roles of the mammalian Chk1 and Chk2 kinases as key signal transducers within the complex network of genome integrity checkpoints, as candidate tumor suppressors disrupted in sporadic as well as some hereditary malignancies and as potential targets of new anticancer therapies.}, address = {Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark. bartek@biobase.dk}, author = {Bartek, J. and Lukas, J.}, citeulike-article-id = {1177547}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12781359}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12781359}, issn = {1535-6108}, journal = {Cancer Cell}, keywords = {cancer, chk1}, month = {May}, number = {5}, pages = {421--429}, posted-at = {2007-03-20 14:25:13}, priority = {2}, title = {Chk1 and Chk2 kinases in checkpoint control and cancer.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12781359}, volume = {3}, year = {2003} }

TY - JOUR ID - citeulike:1177547 L3 - citeulike-article-id:1177547 N2 - Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer cells. This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways. Here, we discuss the emerging roles of the mammalian Chk1 and Chk2 kinases as key signal transducers within the complex network of genome integrity checkpoints, as candidate tumor suppressors disrupted in sporadic as well as some hereditary malignancies and as potential targets of new anticancer therapies. IS - 5 JF - Cancer Cell SN - 1535-6108 AD - Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark. bartek@biobase.dk EP - 429 TI - Chk1 and Chk2 kinases in checkpoint control and cancer. VL - 3 SP - 421 KW - cancer KW - chk1 AU - Bartek, J AU - Lukas, J PY - 2003/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/12781359 ER -