Telomere maintenance and DNA replication: how closely are these two connected? Export

@article{citeulike:1177560, abstract = {The maintenance of the DNA at chromosome ends, the telomeres, depends on conventional semiconservative replication and on the action of telomerase, a specialized reverse transcriptase. Current research strongly suggests a regulatory interplay between this conventional semiconservative replication and telomerase, thus ensuring that no sequences are lost at the very ends of the telomeres during replication. Here, we describe recent findings on the interactions between the conventional replication machinery and telomere replication, and we discuss how DNA-integrity checkpoints might impinge on both the processing of the telomeric DNA ends and the establishment of the DNA end structure required for end protection and genome stability.}, address = {Department of Microbiology and Infectiology, Faculty of Medicine, Universit\'{e} de Sherbrooke, 3001 12th Ave N., Sherbrooke (QC), Canada J1H 5N4.}, author = {Chakhparonian, M. and Wellinger, R. J.}, citeulike-article-id = {1177560}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12902162}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12902162}, issn = {0168-9525}, journal = {Trends Genet}, keywords = {review, stabllity, telomereprotiens}, month = {August}, number = {8}, pages = {439--446}, posted-at = {2007-03-20 14:32:04}, priority = {2}, title = {Telomere maintenance and DNA replication: how closely are these two connected?}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12902162}, volume = {19}, year = {2003} }

TY - JOUR ID - citeulike:1177560 L3 - citeulike-article-id:1177560 N2 - The maintenance of the DNA at chromosome ends, the telomeres, depends on conventional semiconservative replication and on the action of telomerase, a specialized reverse transcriptase. Current research strongly suggests a regulatory interplay between this conventional semiconservative replication and telomerase, thus ensuring that no sequences are lost at the very ends of the telomeres during replication. Here, we describe recent findings on the interactions between the conventional replication machinery and telomere replication, and we discuss how DNA-integrity checkpoints might impinge on both the processing of the telomeric DNA ends and the establishment of the DNA end structure required for end protection and genome stability. IS - 8 JF - Trends Genet SN - 0168-9525 AD - Department of Microbiology and Infectiology, Faculty of Medicine, Université de Sherbrooke, 3001 12th Ave N., Sherbrooke (QC), Canada J1H 5N4. EP - 446 TI - Telomere maintenance and DNA replication: how closely are these two connected? VL - 19 SP - 439 KW - review KW - stabllity KW - telomereprotiens AU - Chakhparonian, M AU - Wellinger, RJ PY - 2003/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/12902162 ER -