Hayflick, his limit, and cellular ageing. Export

@article{citeulike:1185500, abstract = {Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent -- a phenomenon now known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.}, address = {University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA. shay@utsw.swmed.edu}, author = {Shay, J. W. and Wright, W. E.}, citeulike-article-id = {1185500}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/35036093}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11413492}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11413492}, doi = {10.1038/35036093}, issn = {1471-0072}, journal = {Nat Rev Mol Cell Biol}, keywords = {aging, hayflick, review, senescence}, month = {October}, number = {1}, pages = {72--76}, posted-at = {2007-03-24 19:40:52}, priority = {2}, title = {Hayflick, his limit, and cellular ageing.}, url = {http://dx.doi.org/10.1038/35036093}, volume = {1}, year = {2000} }

TY - JOUR ID - citeulike:1185500 L3 - citeulike-article-id:1185500 N2 - Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent -- a phenomenon now known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing. IS - 1 JF - Nat Rev Mol Cell Biol SN - 1471-0072 AD - University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA. shay@utsw.swmed.edu EP - 76 TI - Hayflick, his limit, and cellular ageing. VL - 1 SP - 72 KW - aging KW - hayflick KW - review KW - senescence AU - Shay, JW AU - Wright, WE PY - 2000/10// UR - http://dx.doi.org/10.1038/35036093 ER -