Evidence for a new step in telomere maintenance. Export

@article{citeulike:1186327, abstract = {The strand of telomeric DNA that runs 5'-3' toward a chromosome end is typically G rich. Telomerase-generated G tails are expected at one end of individual DNA molecules. Saccharomyces telomeres acquire TG1-3 tails late in S phase. Moreover, the telomeres of linear plasmids can interact when the TG1-3 tails are present. Molecules that mimic the structures predicted for telomere replication intermediates were generated in vitro. These in vitro generated molecules formed telomere-telomere interactions similar to those on molecules isolated from yeast, but only if both ends that interacted had a TG1-3 tail. Moreover, TG1-3 tails were generated in vivo in cells lacking telomerase. These data suggest a new step in telomere maintenance, cell cycle-regulated degradation of the C1-3A strand, which can generate a potential substrate for telomerase and telomere-binding proteins at every telomere.}, address = {Department of Microbiology, Faculty of Medicine, Universit\'{e} de Sherbrooke, Quebec, Canada.}, author = {Wellinger, R. J. and Ethier, K. and Labrecque, P. and Zakian, V. A.}, citeulike-article-id = {1186327}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8616897}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8616897}, day = {3}, issn = {0092-8674}, journal = {Cell}, keywords = {capping, endreplication, overhang}, month = {May}, number = {3}, pages = {423--433}, posted-at = {2007-03-25 19:37:51}, priority = {2}, title = {Evidence for a new step in telomere maintenance.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8616897}, volume = {85}, year = {1996} }

TY - JOUR ID - citeulike:1186327 L3 - citeulike-article-id:1186327 N2 - The strand of telomeric DNA that runs 5'-3' toward a chromosome end is typically G rich. Telomerase-generated G tails are expected at one end of individual DNA molecules. Saccharomyces telomeres acquire TG1-3 tails late in S phase. Moreover, the telomeres of linear plasmids can interact when the TG1-3 tails are present. Molecules that mimic the structures predicted for telomere replication intermediates were generated in vitro. These in vitro generated molecules formed telomere-telomere interactions similar to those on molecules isolated from yeast, but only if both ends that interacted had a TG1-3 tail. Moreover, TG1-3 tails were generated in vivo in cells lacking telomerase. These data suggest a new step in telomere maintenance, cell cycle-regulated degradation of the C1-3A strand, which can generate a potential substrate for telomerase and telomere-binding proteins at every telomere. IS - 3 JF - Cell SN - 0092-8674 AD - Department of Microbiology, Faculty of Medicine, Université de Sherbrooke, Quebec, Canada. EP - 433 TI - Evidence for a new step in telomere maintenance. VL - 85 SP - 423 KW - capping KW - endreplication KW - overhang AU - Wellinger, RJ AU - Ethier, K AU - Labrecque, P AU - Zakian, VA PY - 1996/05/03/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8616897 ER -