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Switching and signaling at the telomere. Export

Cell, Vol. 106, No. 6. (21 September 2001), pp. 661-673.

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capping damageresponse senescence telomerasemechanism

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This review describes the structure of telomeres, the protective DNA-protein complexes at eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere functions. Also discussed are cellular responses to compromising the functions of telomeres and of telomerase, which synthesizes telomeric DNA.


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