Protection of mammalian telomeres. Export

@article{citeulike:970570, abstract = {Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. It is not clear exactly how the structure of telomere ends differs from sites of DNA damage and how telomeres protect chromosome ends from DNA repair activities. What are the defining structural features of telomeres and through which mechanisms do they ensure chromosome end protection? What is the molecular basis of the telomeric cap and how does it act to sequester the chromosome end? Here I discuss data gathered in the last few years, suggesting that the protection of human chromosome ends primarily depends on the telomeric protein TRF2 and that telomere capping involves the formation of a higher order structure, the telomeric loop or t-loop.}, address = {Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA. delange@mail.rockefeller.edu}, author = {de Lange, T.}, citeulike-article-id = {970570}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.onc.1205080}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11850778}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11850778}, day = {21}, doi = {10.1038/sj.onc.1205080}, issn = {0950-9232}, journal = {Oncogene}, keywords = {senescence, shelterin}, month = {January}, number = {4}, pages = {532--540}, posted-at = {2007-05-01 21:24:26}, priority = {2}, title = {Protection of mammalian telomeres.}, url = {http://dx.doi.org/10.1038/sj.onc.1205080}, volume = {21}, year = {2002} }

TY - JOUR ID - citeulike:970570 L3 - citeulike-article-id:970570 N2 - Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. It is not clear exactly how the structure of telomere ends differs from sites of DNA damage and how telomeres protect chromosome ends from DNA repair activities. What are the defining structural features of telomeres and through which mechanisms do they ensure chromosome end protection? What is the molecular basis of the telomeric cap and how does it act to sequester the chromosome end? Here I discuss data gathered in the last few years, suggesting that the protection of human chromosome ends primarily depends on the telomeric protein TRF2 and that telomere capping involves the formation of a higher order structure, the telomeric loop or t-loop. IS - 4 JF - Oncogene SN - 0950-9232 AD - Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA. delange@mail.rockefeller.edu EP - 540 TI - Protection of mammalian telomeres. VL - 21 SP - 532 KW - senescence KW - shelterin AU - de Lange, T PY - 2002/01/21/ UR - http://dx.doi.org/10.1038/sj.onc.1205080 ER -